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. 2021 Aug 9:2021:9761159.
doi: 10.1155/2021/9761159. eCollection 2021.

Clinical Efficacy of Qili Qiangxin Capsule Combined with Western Medicine in the Treatment of Chronic Heart Failure: A Systematic Review and Meta-Analysis

Xiaoming Xu  1 , Yang Yang  2 , Gendong Zhou  2 , Zhengxuan Du  2 , Xiaohong Zhang  2 , Wei Mao  1 , Hongwen Cai  1
Affiliations

Clinical Efficacy of Qili Qiangxin Capsule Combined with Western Medicine in the Treatment of Chronic Heart Failure: A Systematic Review and Meta-Analysis

Xiaoming Xu et al. Evid Based Complement Alternat Med. .

Abstract

Qili Qiangxin capsule (QQC) is a formulation of traditional Chinese medicine commonly used for the treatment of heart failure in China. This meta-analysis aimed to assess the clinical efficacy of QQC combined with western medicine in the treatment of chronic heart failure (CHF). We conducted a systematic review and meta-analysis abided by the PRISMA guidelines. Literature search was conducted in the China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journals Database, PubMed, and Web of Science from inception to August 2020. A total of 52 eligible studies were obtained, and 42 of these studies were included in the meta-analysis. The results showed that, compared with western medicine alone, the combination of Qili Qingxin capsule and Western medicine treatment has better efficacy (metoprolol: RR: 1.24, 95%CI 1.14-1.34; carvedilol: RR: 1.24, 95%CI 1.14-1.34; trimetazidine: RR: 1.20, 95%CI: 1.12-1.27; sacubitril valsartan sodium: RR: 1.23, 95%CI: 1.11-1.36; sodium nitroprusside: RR: 1.33, 95%CI: 1.23-1.45; and bisoprolol: RR: 1.31, 95%CI: 1.15-1.49) and increased the level of LVEF, LVEDD, and 6MWT of patients with CHF and reduced the adverse effects and the level of HR, LVESD, BNP, and Hs-cTnT as well. However, there is high heterogeneity in the meta-analysis of LVEDV, BNP, NT-proBNP, Hs-cTnT, 6MWT, and adverse effects, and the methodological quality of the included studies was poor. Therefore, further studies with good methodological quality and large sample size are required to validate our findings. In our study, evidence suggests that Qili Qiangxin capsule combined with Western medicine may improve therapeutic effect and the quality of life of patients with CHF.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of study searching and selection.
Figure 2
Figure 2
Risk of bias summary.
Figure 3
Figure 3
Forest plot of QQC plus Western medicine treatment versus Western medicine only for clinical efficiency (part 1). QQC: Qili Qiangxin capsule.
Figure 4
Figure 4
Forest plot of QQC plus Western medicine treatment versus Western medicine only for clinical efficiency (part 2). QQC: Qili Qiangxin capsule, SVS: aacubitril valsartan sodium, and SN: sodium nitroprusside.
Figure 5
Figure 5
Forest plot of QQC plus Western medicine treatment versus Western medicine only for HR. QQC: Qili Qiangxin capsule, HR: heart rate.
Figure 6
Figure 6
Forest plot of QQC plus Western medicine treatment versus Western medicine only for LVEF (part 1). QQC: Qili Qiangxin capsule, LVEF: left ventricular ejection fractions.
Figure 7
Figure 7
Forest plot of QQC plus Western medicine treatment versus Western medicine only for LVEF (part 2). QQC: Qili Qiangxin capsule, SVS: sacubitril valsartan sodium, SN: sodium nitroprusside, LVEF: left ventricular ejection fractions.
Figure 8
Figure 8
Forest plot of QQC plus Western medicine treatment versus Western medicine only for LVEDD. QQC: Qili Qiangxin capsule, SN: sodium nitroprusside, LVEDD: left ventricular end-diastolic dimension.
Figure 9
Figure 9
Forest plot of QQC plus Western medicine treatment versus Western medicine only for LVEDV. QQC: Qili Qiangxin capsule, LVEDV: left ventricular end-diastolic volume.
Figure 10
Figure 10
Forest plot of QQC plus Western medicine treatment versus Western medicine only for LVESD. QQC: Qili Qiangxin capsule, SN: sodium nitroprusside, LVESD: left ventricular end-systolic diameter.
Figure 11
Figure 11
Forest plot of QQC plus Western medicine treatment versus Western medicine only for BNP. QQC: Qili Qiangxin capsule, BNP: brain natriuretic peptide.
Figure 12
Figure 12
Forest plot of QQC plus Western medicine treatment versus Western medicine only for NT-proBNP. QQC: Qili Qiangxin capsule, SVS: sacubitril valsartan sodium, NT-proBNP: N-terminal pro-B-type natriuretic peptide.
Figure 13
Figure 13
Forest plot of QQC plus Western medicine treatment versus Western medicine only for Hs-cTnT. QQC: Qili Qiangxin capsule, Hs-cTnT: high-sensitivity cardiac troponin T.
Figure 14
Figure 14
Forest plot of QQC plus Western medicine treatment versus Western medicine only for 6MWT. QQC: Qili Qiangxin capsule, 6MWT: 6-min walk test.
Figure 15
Figure 15
Forest plot of QQC plus Western medicine treatment versus Western medicine only for adverse effects. QQC: Qili Qiangxin capsule.
See this image and copyright information in PMC

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