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. 2021 Jul 14;13(7):e16389.
doi: 10.7759/cureus.16389. eCollection 2021 Jul.

Role of Mean Platelet Volume in the Prognosis of Gallbladder Carcinoma: A Tertiary Centre Experience

Prakash Bv  1 , Ali Z Anwar  1 , Raghavendra Harsha  1 , Praveen R Arakeri  1 , Pavan Jonnada  1
Affiliations

Role of Mean Platelet Volume in the Prognosis of Gallbladder Carcinoma: A Tertiary Centre Experience

Prakash Bv et al. Cureus. .

Abstract

Mean platelet volume (MPV) is an inflammatory marker indicative of platelet activation. There are several studies that suggest an association between the neoplastic process and cancer metastasis. We performed a retrospective analysis to investigate the role of MPV as a prognostic informative marker in gallbladder cancer. This study included 73 patients who underwent treatment for gallbladder cancer with curative or palliative intent. MPV was obtained and statistically analysed to investigate the association between the nodal status (N), the overall stage as per the American Joint Committee on Cancer (AJCC) staging system, perineural invasion, and differentiation of the tumor. The statistical analysis was done using SPSS Statistics, version 23 (IBM Corp., Armonk, NY). We found that the MPV values were significantly high in node-positive cases (OR = 3.623, 95% CI = 7.778-1.687, p value = -0.0001), cases in the advanced stage (OR = 3.623, 95% CI = 7.778-1.687, p value = 0.0001), cases with perineural invasion (OR = 3.396, 95% CI = 8.319-1.387, p value = -0.0001), and poor differentiation (OR = 2.327, 95% CI = 4.651-1.164, p value = -0.002 ). MPV is an inexpensive and convenient inflammatory marker that correlates with nodal positivity in the staging and prognostication of gallbladder cancer. This marker can be used to ascertain the risk status of gallbladder cancer.

Keywords: diagnosis; gall bladder cancer; lymph node status; mean platelet volume; overall stage.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Receiver-operating characteristic curve analysis showing the mean platelet volume cutoff
Figure 2
Figure 2. Relationship between mean platelet volume and nodal status
Figure 3
Figure 3. Relationship between mean platelet volume and American Joint Committee on Cancer stage
Figure 4
Figure 4. Relationship between mean platelet volume and perineural invasion
Figure 5
Figure 5. Relationship between mean platelet volume and differentiation
See this image and copyright information in PMC

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