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. 2021 Apr 17;8(8):ofab142.
doi: 10.1093/ofid/ofab142. eCollection 2021 Aug.

Clinical Effectiveness of Lyme Vaccine: A Matched Case-Control Study

Carlos R Oliveira  1 , Christopher Massad  2 , Eugene D Shapiro  1   2 , Marietta Vazquez  1
Affiliations

Clinical Effectiveness of Lyme Vaccine: A Matched Case-Control Study

Carlos R Oliveira et al. Open Forum Infect Dis. .

Abstract

We conducted a matched case-control study to assess the effectiveness of Lyme vaccine (LYMErix) as it was used in clinical practice. We found ≥3 doses to be 71% effective against Lyme disease. This is the first study to show that the Lyme vaccine is effective in a real-world setting.

Keywords: LYMErix; Lyme vaccine; postlicensure; vaccine effectiveness.

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Figures

Figure 1.
Figure 1.
Effectiveness of Lyme vaccine by number of doses received. aAdjusting for sex, level of education, occupational exposure, having pets, use of protective clothing while outdoors, use of tick repellents, and use of acaricides at home. Abbreviations: mOR, matched odds ratio; VE, vaccine effectiveness.
See this image and copyright information in PMC

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