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Clinical Trial
. 1987;25(6):493-500.
doi: 10.3109/15563658708992652.

Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse

A J Giannini  1 , R H Loiselle, M C Giannini
Affiliations
Clinical Trial

Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse

A J Giannini et al. J Toxicol Clin Toxicol. 1987.

Abstract

Twenty male combinative cocaine free-base/phencyclidine (space-base) abusers were studied for forty-five days, in a double-blind design. Treatment with desipramine was significantly more effective than placebo in alleviating abstinence symptoms. This study tends to support the catecholamine-depletion hypothesis of cocaine and phencyclidine withdrawal.

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