A Case of Topical Ofloxacin-Induced Otomycosis and Literature Review

Mohamed Mahdi Alshahni^{1

2}, Rima Zakzuk Alshahni³, Ryuichi Fujisaki⁴, Takashi Tamura³, Yuya Shimizu⁵, Chiaki Yamanishi³, Koichi Makimura^{6

7

8}

Affiliations

¹ Laboratory of Medical Mycology and Space Environmental Medicine, School of Medicine, Graduate School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan.
² Department of AMR Mycosis Control Research in the Environment of Treatment and Education for Physically and Mentally Handicapped Persons, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, Japan.
³ Teikyo University Institute of Medical Mycology, Tokyo, Japan.
⁴ Department of Sports and Medical Science, Faculty of Medical Technology, Teikyo University, Itabashi, Tokyo, Japan.
⁵ Department of Otolaryngology, Teikyo University Hospital, Itabashi, Tokyo, Japan.
⁶ Laboratory of Medical Mycology and Space Environmental Medicine, School of Medicine, Graduate School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan. makimura@med.teikyo-u.ac.jp.
⁷ Department of AMR Mycosis Control Research in the Environment of Treatment and Education for Physically and Mentally Handicapped Persons, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, Japan. makimura@med.teikyo-u.ac.jp.
⁸ Teikyo University Institute of Medical Mycology, Tokyo, Japan. makimura@med.teikyo-u.ac.jp.

PMID: 34410567
DOI: 10.1007/s11046-021-00581-x

Review

A Case of Topical Ofloxacin-Induced Otomycosis and Literature Review

Mohamed Mahdi Alshahni et al. Mycopathologia. 2021 Dec.

. 2021 Dec;186(6):871-876.

doi: 10.1007/s11046-021-00581-x. Epub 2021 Aug 19.

Authors

Mohamed Mahdi Alshahni^{1

2}, Rima Zakzuk Alshahni³, Ryuichi Fujisaki⁴, Takashi Tamura³, Yuya Shimizu⁵, Chiaki Yamanishi³, Koichi Makimura^{6

7

8}

Affiliations

¹ Laboratory of Medical Mycology and Space Environmental Medicine, School of Medicine, Graduate School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan.
² Department of AMR Mycosis Control Research in the Environment of Treatment and Education for Physically and Mentally Handicapped Persons, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, Japan.
³ Teikyo University Institute of Medical Mycology, Tokyo, Japan.
⁴ Department of Sports and Medical Science, Faculty of Medical Technology, Teikyo University, Itabashi, Tokyo, Japan.
⁵ Department of Otolaryngology, Teikyo University Hospital, Itabashi, Tokyo, Japan.
⁶ Laboratory of Medical Mycology and Space Environmental Medicine, School of Medicine, Graduate School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan. makimura@med.teikyo-u.ac.jp.
⁷ Department of AMR Mycosis Control Research in the Environment of Treatment and Education for Physically and Mentally Handicapped Persons, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, Japan. makimura@med.teikyo-u.ac.jp.
⁸ Teikyo University Institute of Medical Mycology, Tokyo, Japan. makimura@med.teikyo-u.ac.jp.

PMID: 34410567
DOI: 10.1007/s11046-021-00581-x

Abstract

The prevalence of fungal otitis externa, or otomycosis, has been increasing in recent decades. Fungi may act as primary pathogens in this condition, or they may occur as secondary infections after prolonged ototopical treatment with antibiotics, which alters the flora of the external auditory canal (EAC) and enables overgrowth of its fungal inhabitants. We report here a case of otomycosis by Candida parapsilosis, Malassezia obtusa, and Malassezia furfur as a secondary infection following prolonged otic ofloxacin treatment. To the best of our knowledge, although isolation of C. parapsilosis and M. furfur from the EAC is not uncommon, the recovery of M. obtusa has not yet been reported. We also conducted a literature review of the searchable data on PubMed concerning the isolation of Malassezia species from the human EAC.

Keywords: Candida; Malassezia; Ofloxacin; Otitis externa; Otomycosis.

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References

1. Sander R. Otitis externa: a practical guide to treatment and prevention. Am Fam Physician. 2001;63:927–42. - PubMed
1. Dibb WL. Microbial aetiology of otitis externa. J Infect. 1991;22:233–9. - DOI
1. Ho T, Vrabec JT, Yoo D, Coker NJ. Otomycosis: clinical features and treatment implications. Otolaryngol Head Neck Surg. 2006;135:787–91. - DOI
1. Munguia R, Daniel SJ. Ototopical antifungals and otomycosis: a review. Int J Pediatr Otorhinolaryngol. 2008;72:453–9. - DOI
1. Viswanatha B, Naseeruddin K. Fungal infections of the ear in immunocompromised host: a review. Mediterr J Hematol Infect Dis. 2011;3:e2011003.

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A Case of Topical Ofloxacin-Induced Otomycosis and Literature Review

Affiliations

A Case of Topical Ofloxacin-Induced Otomycosis and Literature Review

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Supplementary concepts

Grants and funding

LinkOut - more resources

Full Text Sources