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Editorial
. 2021 Aug 20;129(5):527-529.
doi: 10.1161/CIRCRESAHA.121.319785. Epub 2021 Aug 19.

GDP in Dialysis Associates With Peritoneal Vascular Remodeling in Kidney Disease

Qimei Han  1 , Zyare J Orr  1   2 , Godfrey K Desouza  1   3 , Zsolt Bagi  4 , R Daniel Rudic  1
Affiliations
Editorial

GDP in Dialysis Associates With Peritoneal Vascular Remodeling in Kidney Disease

Qimei Han et al. Circ Res. .

Erratum in

No abstract available

Keywords: Editorials; glucose; inflammation; omentum; peritoneum; vascular remodeling.

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Figures

Figure.
Figure.. High GDPs in dialysis solutions induce vascular remodeling in omental arterioles.
Heat sterilization of dialysis fluid can cause glucose to (at least) in part deteriorate into glucose degradation products. The current work finds that patients treated with dialysis fluid that are especially high in these glucose degradation products results in increased pathological remodeling in arterioles of the omentum (peritoneal membrane that hangs from the stomach). Further, the authors find advanced glycation products (distinct biochemically from glucose degradation products) are upregulated in the abdominal fluid from the children with high GDP, The study subjects in this article are children with chronic kidney disease who were treated by peritoneal dialysis.
See this image and copyright information in PMC

Comment on

  • Glucose Derivative Induced Vasculopathy in Children on Chronic Peritoneal Dialysis.
    Bartosova M, Zhang C, Schaefer B, Herzog R, Ridinger D, Damgov I, Levai E, Marinovic I, Eckert C, Romero P, Sallay P, Ujszaszi A, Unterwurzacher M, Wagner A, Hildenbrand G, Warady BA, Schaefer F, Zarogiannis SG, Kratochwill K, Schmitt CP. Bartosova M, et al. Circ Res. 2021 Aug 20;129(5):e102-e118. doi: 10.1161/CIRCRESAHA.121.319310. Epub 2021 Jul 8. Circ Res. 2021. PMID: 34233458

References

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