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. 2021 Sep-Oct;35(5):2923-2928.
doi: 10.21873/invivo.12583.

Association Between S100b Levels and COVID-19 Pneumonia: A Case Control Study

Ergun Mete  1 , Ramazan Sabirli  2 , Tarik Goren  3 , Ibrahim Turkcuer  3 , Özgür Kurt  4 , Aylin Koseler  5
Affiliations

Association Between S100b Levels and COVID-19 Pneumonia: A Case Control Study

Ergun Mete et al. In Vivo. 2021 Sep-Oct.

Abstract

Background/aim: Extracellular S100b effects are mediated by the receptor for advanced glycation end products (RAGE), which is the S100b membrane receptor. RAGE belongs to the immunoglobulin superfamily of cell surface molecules and serves as a multiligand receptor and is expressed in high abundance by alveolar type I (AT-I) cells in adult pulmonary tissue. This study aimed to provide an insight into the association between the severity of COVID-19 disease and serum S100b levels during admission to the emergency department (ED).

Patients and methods: A total of 64 patients (34 mild cases; 30 severe cases) were diagnosed with COVID-19 pneumonia and 30 healthy volunteers were admitted to study. Serum S100b levels were measured by using enzymle linked immunoassay method from blood serum samples.

Results: Serum S100b levels showed a significantly higher mean value in mild and severe disease cohorts than in healthy controls (p=0.036 and p=0.028 respectively). Receiver operating characteristic (ROC) analysis indicated greater area under the curve (AUC) for serum S100b levels of the COVID-19 patients (AUC=0.663, 95% CI=0.541-0.785; p=0.014). In addition, serum S100b concentration was measured as 151.7 ng/ml at 79.3% sensitivity and 51.7% specificity (p=0.014). Serum S100b protein levels can serve as a valuable clinical marker in establishing diagnosis of patients. Though not useful in identifying different stages of COVID-19 infection, serum S100b concentration along with other known markers can be utilized to reliably predict clinical severity along with other clinical parameters.

Keywords: COVID-19; S100b levels; pneumonia.

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Conflict of interest statement

The Authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Receiver operator curve (ROC) analysis of S100B protein levels.
See this image and copyright information in PMC

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