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. 2021 Aug 20;70(33):1114-1119.
doi: 10.15585/mmwr.mm7033a2.

Disparities in Excess Mortality Associated with COVID-19 - United States, 2020

Disparities in Excess Mortality Associated with COVID-19 - United States, 2020

Lauren M Rossen et al. MMWR Morb Mortal Wkly Rep. .

Abstract

The COVID-19 pandemic has disproportionately affected Hispanic or Latino, non-Hispanic Black (Black), non-Hispanic American Indian or Alaska Native (AI/AN), and non-Hispanic Native Hawaiian or Other Pacific Islander (NH/PI) populations in the United States. These populations have experienced higher rates of infection and mortality compared with the non-Hispanic White (White) population (1-5) and greater excess mortality (i.e., the percentage increase in the number of persons who have died relative to the expected number of deaths for a given place and time) (6). A limitation of existing research on excess mortality among racial/ethnic minority groups has been the lack of adjustment for age and population change over time. This study assessed excess mortality incidence rates (IRs) (e.g., the number of excess deaths per 100,000 person-years) in the United States during December 29, 2019-January 2, 2021, by race/ethnicity and age group using data from the National Vital Statistics System. Among all assessed racial/ethnic groups (non-Hispanic Asian [Asian], AI/AN, Black, Hispanic, NH/PI, and White populations), excess mortality IRs were higher among persons aged ≥65 years (426.4 to 1033.5 excess deaths per 100,000 person-years) than among those aged 25-64 years (30.2 to 221.1) and those aged <25 years (-2.9 to 14.1). Among persons aged <65 years, Black and AI/AN populations had the highest excess mortality IRs. Among adults aged ≥65 years, Black and Hispanic persons experienced the highest excess mortality IRs of >1,000 excess deaths per 100,000 person-years. These findings could help guide more tailored public health messaging and mitigation efforts to reduce disparities in mortality associated with the COVID-19 pandemic in the United States,* by identifying the racial/ethnic groups and age groups with the highest excess mortality rates.

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Conflict of interest statement

All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Zhenqiu Lin reports contract support from the Centers for Medicare & Medicaid Services (CMS) to develop and maintain measures of hospital performance that are publicly reported. Harlan M. Krumholz reports the following outside the current work: honoraria for presentations at various educational events; grants from Medtronic and the Food and Drug Administration, Medtronic and Johnson & Johnson, Shenzhen Center for Health Information, Foundation for a Smoke-Free World, and Connecticut Department of Public Health and CMS; payment from law firms Martin/Baughman, Arnold & Porter, and Siegfried & Jensen for expert testimony; chairmanship or member of United Healthcare cardiac scientific advisory board, IBM Watson Health life sciences board, Element Science scientific advisor, Aetna health care advisory board, and Facebook advisory board; and ownership of Hugo Health and Refractor Health. No other potential conflicts of interest were disclosed.

Figures

FIGURE 1
FIGURE 1
Weekly percentage excess all-cause mortality for persons aged <25 years (A), 25–64 years (B), and ≥65 years (C), by race/ethnicity — United States, 2020 Abbreviations: AI/AN = American Indian/Alaska Native; NH/PI = Native Hawaiian/Other Pacific Islander; sARIMA = seasonal autoregressive integrated moving average. * Weekly numbers of deaths from all causes by age group and race/ethnicity were obtained from the National Vital Statistics System. The expected numbers of deaths were estimated using sARIMA models of weekly all-cause mortality incidence rates (deaths per 100,000 population-weeks) from 2015–2019, multiplied by the weekly population projections during December 29, 2019–January 2, 2021. The percentage excess corresponds to the number of excess deaths divided by the expected number of deaths. Weeks 1–53 of 2020 are shown. The scale of the y-axis differs for each age group. AI/AN, Asian, Black, NH/PI, and White persons were non-Hispanic; Hispanic persons could be of any race.
FIGURE 2
FIGURE 2
Quarterly excess all-cause mortality incidence rates and annual excess incidence rates for persons aged <25 years (A), 25–64 years (B), and ≥65 years (C), by race/ethnicity — United States, 2020 Abbreviations: AI/AN = American Indian/Alaska Native; IR = incidence rates; NH/PI = Native Hawaiian/Other Pacific Islander. * Excess deaths per 100,000 person-quarters. Annual excess death IRs for Hispanic, AI/AN, Asian, Black, NH/PI, and White persons were as follows: aged <25 years: 3.3, 6.5, −2.9, 14.1, −1.0, and 2.2, respectively; aged 25–64 years: 98.5, 221.1, 30.2, 133.4, 124.9, and 51.2, respectively; aged ≥65 years: 1,007.0, 650.0, 483.7, 1,033.5, 426.4, and 500.1, respectively. § AI/AN, Asian, Black, NH/PI, and White persons were non-Hispanic; Hispanic persons could be of any race. Weeks 1–52 (week 53 omitted to ensure each quarter consisted of 13 weeks and the four quarters summed to the total). The scale of the y-axis differs for each age group. ** Negative excess mortality IRs mean that there were fewer deaths than expected for that group.

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