Lysosome-targeting chimeras evolve

Affiliations

Comment

Joshiawa Paulk. Nat Chem Biol. 2021 Sep.

. 2021 Sep;17(9):931-933.

doi: 10.1038/s41589-021-00835-1.

¹ Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Cambridge, MA, USA. josh.paulk@novartis.com.

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LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation.
Ahn G, Banik SM, Miller CL, Riley NM, Cochran JR, Bertozzi CR. Ahn G, et al. Nat Chem Biol. 2021 Sep;17(9):937-946. doi: 10.1038/s41589-021-00770-1. Epub 2021 Mar 25. Nat Chem Biol. 2021. PMID: 33767387 Free PMC article.
Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins.
Zhou Y, Teng P, Montgomery NT, Li X, Tang W. Zhou Y, et al. ACS Cent Sci. 2021 Mar 24;7(3):499-506. doi: 10.1021/acscentsci.1c00146. Epub 2021 Mar 4. ACS Cent Sci. 2021. PMID: 33791431 Free PMC article.
Bifunctional small molecules that mediate the degradation of extracellular proteins.
Caianiello DF, Zhang M, Ray JD, Howell RA, Swartzel JC, Branham EMJ, Chirkin E, Sabbasani VR, Gong AZ, McDonald DM, Muthusamy V, Spiegel DA. Caianiello DF, et al. Nat Chem Biol. 2021 Sep;17(9):947-953. doi: 10.1038/s41589-021-00851-1. Epub 2021 Aug 19. Nat Chem Biol. 2021. PMID: 34413525

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