Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;45(11):2973-2981.
doi: 10.1007/s00264-021-05161-8. Epub 2021 Aug 19.

Comparable outcomes of recycled autografts and allografts for reconstructions in patients with high-grade osteosarcoma

Kuan-Lin Chen  1   2   3 , Chao-Ming Chen  1   2   3   4 , Cheng-Fong Chen  1   2   3 , Yu-Chi Cheng  5 , Yu-Kuan Lin  1   2   3   6 , Shang-Wen Tsai  1   2   3   4 , Tain-Hsiung Chen  1   2 , Po-Kuei Wu  7   8   9   10 , Wei-Ming Chen  1   2   3
Affiliations

Comparable outcomes of recycled autografts and allografts for reconstructions in patients with high-grade osteosarcoma

Kuan-Lin Chen et al. Int Orthop. 2021 Nov.

Abstract

Purpose: This retrospective, single-centre study compares the clinical and radiographic outcomes of limb reconstruction using recycled autografts to that using allografts.

Methods: Patients with histopathologically verified high-grade osteosarcoma treated with wide bone resection and limb reconstruction using allografts or recycled autografts from January 1998 through December 2012 were retrospectively screened for enrolment eligibility. The final study cohort included 255 patients (allograft, 91; recycled autograft, 164). Data regarding post-operative complications, salvage treatment, and graft survival were collected. A modified International Society of Limb Salvage classification system was used to evaluate the radiographic findings.

Results: The time to graft-host union did not differ significantly between the two graft types. Patients receiving recycled autografts had fewer complications compared than did those receiving allografts (recycled autografts vs. allograft: structural failure, 4.3 vs. 13.2%; late infection, 2.4 vs. 7.7%; all p < 0.05). Complications occurred most frequently during the first three years after surgery, and the majority were manageable. The five year limb survival rate did not differ significantly between the two graft types (91.3 vs. 94.0%; p = 0.752). No local oncological recurrence was observed within the recycled autografts.

Conclusion: Recycled autografts and allografts are feasible options for biological limb reconstructions in terms of complications and graft survival after wide resection of osteosarcoma.

Keywords: Allograft; Bone reconstruction; Limb salvage; Osteosarcoma; Recycled autograft.

PubMed Disclaimer

References

    1. Siegel RL, Miller KD, Jemal A (2019) Cancer statistics, 2019. CA Cancer J Clin 69:7–34. https://doi.org/10.3322/caac.21551 - DOI
    1. Health Promotion Administration Ministry of Health and Welfare Taiwan. Taiwan Cancer Statistics. 2018. Available at: https://www.hpa.gov.tw/Pages/ashx/File.ashx?FilePath=~/File/Attach/10227... . Accessed December 2019
    1. Misaghi A, Goldin A, Awad M, Kulidjian AA (2018) Osteosarcoma: a comprehensive review. SICOT J 4:12. https://doi.org/10.1051/sicotj/2017028 - DOI - PubMed - PMC
    1. Han G, Bi WZ, Xu M, Jia JP, Wang Y (2016) Amputation versus limb-salvage surgery in patients with osteosarcoma: a meta-analysis. World J Surg 40:2016–2027. https://doi.org/10.1007/s00268-016-3500-7 - DOI - PubMed
    1. Li X, Zhang Y, Wan S et al (2016) A comparative study between limb-salvage and amputation for treating osteosarcoma. J Bone Oncol 5:15–21. https://doi.org/10.1016/j.jbo.2016.01.001 - DOI - PubMed - PMC

Publication types

LinkOut - more resources