Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Jul-Aug;53(4):330-331.
doi: 10.4103/ijp.IJP_553_20.

Nilotinib-induced generalized keratosis pilaris: Report of a rare case

Priyanka Arun Kowe  1 , Vaishali H Wankhade  1 , Sakshi S Malpani  1 , Rajesh P Singh  1
Affiliations
Case Reports

Nilotinib-induced generalized keratosis pilaris: Report of a rare case

Priyanka Arun Kowe et al. Indian J Pharmacol. 2021 Jul-Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

None

Figures

Figure 1
Figure 1
(a and b) Multiple keratotic follicular papules over bilateral upper extremity (c) face (d) and back
Figure 2
Figure 2
(a) scanner view showing hyperkeratotic epidermis and dermis (H and E x4) (b) Epidermis with follicular hyperkeratosis and infundibular dilatation (red arrow), hair follicle with keratin plug (blue arrow), mild perivascular lymphocytic infiltrate in the upper dermis (green arrow) (H and E x40)
See this image and copyright information in PMC

References

    1. Hu JC, Sadeghi P, Pinter-Brown LC, Yasher S, Chiu MW. Cutaneous side effects of epidermal growth factor receptor inhibitors: Clinical presentation, pathogenesis, and management. J Am Acad Dermatol. 2007;56:317–26. - PubMed
    1. Drucker AM, Wu S, Busam KJ, Berman E, Amitay-Laish I, Lacouture ME. Rash with the multitargeted kinase inhibitors nilotinib and dasatinib: Meta-analysis and clinical characterization. Eur J Haematol. 2013;90:142–50. - PubMed
    1. Chang CH, Shih LY, Lu PH. A case of nilotinib-induced keratosis pilaris-like perifollicular fibrosis with a brief review of the literature. Dermatol Sinica. 2017;35:163–5.
    1. Michael D. Ioffreda. Inflammatory Diseases of Hair Follicles, Sweat Glands, and Cartilage. In: Elder DE, editor. Lever’s Histopathology of the Skin. 10th ed. Philadelphia: Lippincott Williams and Wilkins; 2008. p. 469.
    1. Patel AB, Solomon AR, Mauro MJ, Ehst BD. Unique cutaneous reaction to second- and third-generation tyrosine kinase inhibitors for chronic myeloid leukemia. Dermatology. 2016;232:122–5. - PubMed

Supplementary concepts