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Comment
. 2021 Aug 19;184(17):4377-4379.
doi: 10.1016/j.cell.2021.07.031.

Modeling neurodegeneration with mutant-tau organoids

Laura Pellegrini  1 , Madeline A Lancaster  2
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Modeling neurodegeneration with mutant-tau organoids

Laura Pellegrini et al. Cell. .
Free article

Abstract

Greater understanding of the events preceding neurodegeneration is needed to design effective preventive and therapeutic strategies. In this issue of Cell, Bowles et al. (2021) report cerebral organoids that reveal early events in frontotemporal dementia pathogenesis due to mutations in microtubule-associated protein tau (MAPT), shedding light on a novel mechanism involving abnormal splicing and glutamate signaling.

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Conflict of interest statement

Declaration of interests M.A.L. is an inventor on patents based on cerebral organoids and co-founder and scientific advisory board member of a:head bio AG.

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