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Comment
. 2021 Oct;7(10):883-885.
doi: 10.1016/j.trecan.2021.08.003. Epub 2021 Aug 18.

Matrix stiffness primes cells for future oxidative stress

Paul V Taufalele  1 , Cynthia A Reinhart-King  2
Affiliations
Comment

Matrix stiffness primes cells for future oxidative stress

Paul V Taufalele et al. Trends Cancer. 2021 Oct.

Abstract

Focus on metabolic reprogramming has re-emerged in recent years due to the far-reaching consequences of metabolism on nearly all cellular behaviors. In a recent study in Cell Metabolism, Tharp et al. show that adhesion-dependent mechanical signaling induces mitochondrial and metabolic reprogramming to help cells adapt to future oxidative stress.

Keywords: ROS; matrix stiffness; mechanosignaling; mitohormesis.

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Conflict of interest statement

Declaration of interests No interests are declared.

Comment on

  • Adhesion-mediated mechanosignaling forces mitohormesis.
    Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM. Tharp KM, et al. Cell Metab. 2021 Jul 6;33(7):1322-1341.e13. doi: 10.1016/j.cmet.2021.04.017. Epub 2021 May 20. Cell Metab. 2021. PMID: 34019840 Free PMC article.

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