Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;43(11):3448-3458.
doi: 10.1002/hed.26844. Epub 2021 Aug 21.

Development and validation of an improved classification and risk stratification system for carotid body tumors: Multinational collaborative cohort study

Hisham Mehanna  1 , Pankaj Mistry  2 , Pawel Golusinski  3 , Pasquale Di Maio  4 , Paul Nankivell  1 , Francesco Snider  5 , Angela M R Ferrante  5 , Nausica Montalto  6 , Piero Nicolai  6 , Alessandra Marcantoni  7 , Cesare Grandi  7 , Marco Zavatta  8 , Franco Grego  8 , Kataryna Malec  9 , Sefik Hosal  10 , Nilda Suslu  10 , Oguz Kuscu  10 , Ignacio Torrealba  11 , Francisco Valdes  11 , Neil Sharma  1 , John Ayuk  12 , Peter Monksfield  1 , Richard Irving  1 , Janet A Dunn  2 , Mark Kay  13 , Daniele Borsetto  1
Affiliations

Development and validation of an improved classification and risk stratification system for carotid body tumors: Multinational collaborative cohort study

Hisham Mehanna et al. Head Neck. 2021 Nov.

Abstract

Background: This study aims to develop and validate a new classification system that better predicts combined risk of neurological and neurovascular complications following CBT surgery, crucial for treatment decision-making.

Methods: Multinational retrospective cohort study with 199 consecutive cases. A cohort of 132 CBT cases was used to develop the new classification. To undertake external validation, assessment was made between the actual complication rate and predicted risk by the model on an independent cohort (n = 67).

Results: Univariate analyses showed statistically significant associations between developing a complication and the following factors: craniocaudal dimension, volume, Shamblin classification, and Mehanna types. In the multivariate prognostic model, only Mehanna type remained as a significant risk predictor. The risk of developing complications increases with increasing Mehanna type.

Conclusions: We have developed and then validated a new classification and risk stratification system for CBTs, which demonstrated better prognostic power for the risk of developing neurovascular complications after surgery.

Keywords: Shamblin; carotid body tumor; classification; paraganglioma; surgery.

PubMed Disclaimer

References

REFERENCES

    1. Pellitteri PK, Rinaldo A, Myssiorek D, et al. Paragangliomas of the head and neck. Oral Oncol. 2004;40(6):563-575.
    1. Capatina C, Ntali G, Karavitaki N, Grossman AB. The management of head-and-neck paragangliomas. Endocr Relat Cancer. 2013;20(5):R291-R305.
    1. Offergeld C, Brase C, Yaremchuk S, et al. Head and neck paragangliomas: clinical and molecular genetic classification. Clinics. 2012;67(suppl 1):19-28.
    1. Williams MD, Tischler AS. Update from the 4th edition of the World Health Organization Classification of Head and Neck Tumours: Paragangliomas. Head Neck Pathol. 2017;11(1):88-95.
    1. Rodriguez-Cuevas S, Lopez-Garza J, Labastida-Almendaro S. Carotid body tumors in inhabitants of altitudes higher than 2000 meters above sea level. Head Neck. 1998;20(5):374-378.

Publication types

LinkOut - more resources