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Multicenter Study
. 2021 Oct;40(10):1035-1049.
doi: 10.1016/j.healun.2021.07.015. Epub 2021 Jul 29.

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult heart transplantation report - 2021; Focus on recipient characteristics

Kiran K Khush  1 , Eileen Hsich  1 , Luciano Potena  1 , Wida S Cherikh  1 , Daniel C Chambers  1 , Michael O Harhay  1 , Don Hayes Jr  1 , Michael Perch  1 , Aparna Sadavarte  1 , Alice Toll  1 , Tajinder P Singh  1 , Andreas Zuckermann  1 , Josef Stehlik  2 ; International Society for Heart and Lung Transplantation  1
Affiliations
Multicenter Study

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult heart transplantation report - 2021; Focus on recipient characteristics

Kiran K Khush et al. J Heart Lung Transplant. 2021 Oct.
No abstract available

Keywords: heart transplantation; post-transplant survival; recipient characteristics.

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Figures

Figure 1
Figure 1
A: Median recipient age by year and geographic location (transplants: January 1992 - June 2018). B: Median recipient body mass index by year and geographic location (transplants: January 1992 − June 2018). C: Median recipient estimated glomerular filtration rate (Cockcroft-Gault formula) by year and geographic location (transplants: January 1994 − June 2018)
Figure 2
Figure 2
Kaplan-Meier survival within 12 months by location and era (transplants: January 2000-June 2017)
Figure 3
Figure 3
Kaplan-Meier survival within 12 months by location and recipient age (transplants: January 2000-June 2017)
Figure 4
Figure 4
Kaplan-Meier survival within 12 months by recipient panel of reactive antibodies (PRA) and era (transplants: January 2000-June 2017)
Figure 5
Figure 5
Kaplan-Meier survival within 12 months by recipient mechanical circulatory support (MCS) and era (transplants: January 2000-June 2017). VAD. ventricular assist device
Figure 6
Figure 6
Kaplan-Meier survival within 5 years, conditional on survival to 1 year, by location and recipient age (transplants: January 1996-June 2013)
Figure 7
Figure 7
Kaplan-Meier survival within 5 years, conditional on survival to 1 year, by recipient panel of reactive antibodies (PRA) and era (transplants: January 1996-June 2013)
Figure 8
Figure 8
Freedom from cardiac allograft vasculopathy (CAV) conditional on survival to discharge by panel of reactive antibodies (PRA) and era (transplants: January 1996-June 2013)
Figure 9
Figure 9
Freedom from cardiac allograft vasculopathy (CAV) conditional on survival to discharge by recipient diabetes and era (transplants: January 1996-June 2013)
Figure 10
Figure 10
Statistically significant categorical risk factors for 1-year mortality with 95% confidence limits (transplants: January 2000-June 2017; N=67,223). IV: intravenous, ICM: ischemic cardiomyopathy, NICM: non-ischemic cardiomyopathy, CVA: cerebrovascular accident, F: female, M: male, HCM: hypertrophic cardiomyopathy, MCS: mechanical circulatory support, VAD: ventricular assist device, VCM: valvular cardiomyopathy, RETX: retransplant, RCM: restrictive cardiomyopathy, ECMO: extracorporeal membrane oxygenation, CHD: congenital heart disease
Figure 11
Figure 11
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by recipient age (transplants: January 2000-June 2017; N = 67,223)
Figure 12
Figure 12
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by recipient glomerular filtration rate (GFR) (transplants: January 2000-June 2017; N = 67,223). GFR was estimated using the Cockcroft-Gault formula
Figure 13
Figure 13
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by recipient body mass index (BMI) (transplants: January 2000-June 2017; N = 67,223).
Figure 14
Figure 14
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by recipient bilirubin (transplants: January 2000-June 2017; N = 67,223)
Figure 15
Figure 15
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by recipient panel of reactive antibodies (PRA) (transplants: January 2000-June 2017; N = 67,223)
Figure 16
Figure 16
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by transplant center volume in previous three years (transplants: January 2000-June 2017; N = 67,223)
Figure 17
Figure 17
Statistically significant categorical risk factors for 5-year mortality, conditional on survival to 1 year, with 95% confidence limits (transplants: January 1996-June 2013; N=53,105). HCM: hypertrophic cardiomyopathy, NICM: nonischemic cardiomyopathy, CHD: congenital heart disease, F: female, M: male, ICM: ischemic cardiomyopathy, RCM: restrictive cardiomyopathy, RETX: retransplant
Figure 18
Figure 18
Statistically significant categorical risk factors for cardiac allograft vasculopathy (CAV) within 5 years, conditional on survival to discharge, with 95% confidence limits (transplants: January 1996-June 2013; N = 26,554) NICM: nonischemic cardiomyopathy, F: female, M: male, CVA: cerebrovascular accident, ICM: ischemic cardiomyopathy, RETX: retransplant
Figure 19
Figure 19
Multivariable hazard ratio plot for cardiac allograft vasculopathy (CAV) within 5 years with 95% confidence limits, by recipient age (transplants: January 1996-June 2013; N = 26,554)
Figure 20
Figure 20
Multivariable hazard ratio plot for cardiac allograft vasculopathy (CAV) within 5 years with 95% confidence limits, by donor age (transplants: January 1996-June 2013; N = 26,554)
See this image and copyright information in PMC

References

    1. Khush KK, Potena L, Cherikh WS, et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: 37th adult heart transplantation report-2020; focus on deceased donor characteristics. J Heart Lung Transplant 2020;39:1003–15. - PMC - PubMed
    1. Khush KK, Cherikh WS, Chambers DC, et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-sixth adult heart transplantation report - 2019; focus theme: donor and recipient size match. J Heart Lung Transplant 2019;38:1056–66. - PMC - PubMed
    1. Nguyen DM, El-Serag HB. The epidemiology of obesity. Gastroenterol Clin North Am 2010;39:1–7. - PMC - PubMed
    1. Khush KK, Cherikh WS, Chambers DC, et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-fifth adult heart transplantation report2018; focus theme: multiorgan transplantation. J Heart Lung Transplant 2018;37:1155–68. - PubMed
    1. Yalcin YC, Muslem R, Veen KM, et al. Impact of continuous flow left ventricular assist device therapy on chronic kidney disease: a longitudinal multicenter study. J Card Fail 2020;26:333–41. - PubMed

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