Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug 23;31(6):679-684.
doi: 10.1097/SLE.0000000000000973.

Morphologic Change of In Vivo Porcine Liver Under 13 mm Hg Pneumoperitoneum Pressure

Wenyu Zhang  1   2 , Dalong Yin  3   4 , Xiaoxia Chen  5 , Shugeng Zhang  3   4 , Fanzheng Meng  4 , Hongrui Guo  4 , Shuhang Liang  4 , Shuo Zhou  4 , Shuxun Liu  4 , Linmao Sun  4 , Xiao Guo  4 , Huoling Luo  1 , Baochun He  1 , Deqiang Xiao  1 , Wei Cai  4 , Chihua Fang  6 , Lianxin Liu  2   3 , Fucang Jia  1   7
Affiliations

Morphologic Change of In Vivo Porcine Liver Under 13 mm Hg Pneumoperitoneum Pressure

Wenyu Zhang et al. Surg Laparosc Endosc Percutan Tech. .

Abstract

Background: Clinically, the total and residual liver volume must be accurately calculated before major hepatectomy. However, liver volume might be influenced by pneumoperitoneum during surgery. Changes in liver volume change also affect the accuracy of simulation and augmented reality navigation systems, which are commonly first validated in animal models. In this study, the morphologic changes in porcine livers in vivo under 13 mm Hg pneumoperitoneum pressure were investigated.

Materials and methods: Twenty male pigs were scanned with contrast-enhanced computed tomography without pneumoperitoneum and with 13 mm Hg pneumoperitoneum pressure.

Results: The surface area and volume of the liver and the vascular diameter of the aortic lumen, inferior vena cava lumen, and portal vein lumen were measured. There were statistically significant differences in the surface area and volume of the liver (P=0.000), transverse diameter of the portal vein (P=0.038), longitudinal diameter of the inferior vena cava (P=0.033), longitudinal diameter of the portal vein (P=0.036), vascular cross-sectional area of the inferior vena cava (P=0.028), and portal vein (P=0.038) before and after 13 mm Hg pneumoperitoneum pressure.

Conclusions: This study indicated that the creation of pneumoperitoneum at 13 mm Hg pressure in a porcine causes liver morphologic alterations affecting the area and volume, as well as the diameter of a blood vessel.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Heizmann O, Zidowitz S, Bourquain H, et al. Assessment of intraoperative liver deformation during hepatic resection: prospective clinical study. World J Surg. 2010;34:1887–1893.
    1. Zijlmans M, Langø T, Hofstad EF, et al. Navigated laparoscopy−liver shift and deformation due to pneumoperitoneum in an animal model. Minim Invasive Ther Allied Technol. 2012;21:241–248.
    1. Avital S, Itah R, Szomstein S, et al. Correlation of CO2 pneumoperitoneal pressures between rodents and humans. Surg Endosc. 2009;23:50–54.
    1. Niehues SM, Unger JK, Malinowski M, et al. Liver volume measurement: reason of the difference between in vivo CT-volumetry and intraoperative ex vivo determination and how to cope it. Eur J Med Res. 2010;15:345–350.
    1. Chen X, Liu H, Feng L, et al. Effect of carbon dioxide pneumoperitoneal pressure on the ultrastructure of implanted endometriotic lesions in a rat model. Eur J Obstet Gynecol Reprod Biol. 2013;171:319–324.

LinkOut - more resources