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Multicenter Study
. 2021 Oct;40(10):1050-1059.
doi: 10.1016/j.healun.2021.07.022. Epub 2021 Jul 31.

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth pediatric heart transplantation report - 2021; focus on recipient characteristics

Tajinder P Singh  1 , Wida S Cherikh  1 , Eileen Hsich  1 , Daniel C Chambers  1 , Michael O Harhay  1 , Don Hayes Jr  1 , Kiran K Khush  1 , Michael Perch  1 , Luciano Potena  1 , Aparna Sadavarte  1 , Alice E Toll  1 , Andreas Zuckermann  1 , Josef Stehlik  2 ; International Society for Heart and Lung Transplantation  1
Affiliations
Multicenter Study

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth pediatric heart transplantation report - 2021; focus on recipient characteristics

Tajinder P Singh et al. J Heart Lung Transplant. 2021 Oct.
No abstract available

Keywords: children; heart transplantation; pediatric; survival; transplant recipients.

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Conflict of interest statement

Disclosure statement

The authors have no conflicts of interest to disclose. Daniel C. Chambers received travel support from Astellas Pharma, Inc, and serves as a consultant and speaker for Roche Ltd; Kiran K. Khush serves as a consultant and speaker for CareDx, Inc; Josef Stehlik serves as a consultant for Medtronic, received research support from Natera and received funding from ISHLT; Michael Perch receives research funding from Roche, travel support from Boeringer-Ingel-heim, and is a speaker for Mallinckrodt, Glaxo Smith Kline, and Astra-Zeneca; Wida S. Cherikh, Aparna Sadavarte, and Alice Toll received funding from ISHLT; Don Hayes, Jr.; Michael O. Harhay; Eileen Hsich; Luciano Potena; and Tajinder P. Singh do not have any relevant disclosures.

Figures

Figure 1
Figure 1
Recipient diagnosis by location and era (January 1992-June 2018).
Figure 2
Figure 2
Kaplan-Meier survival within 12-months by location and era (January 2000-June 2017).
Figure 3
Figure 3
Kaplan-Meier survival within 12-months by recipient age and era (January 2000-June 2017).
Figure 4
Figure 4
Kaplan-Meier survival within 12-months by recipient diagnosis and era (January 2000-June 2017).
Figure 5
Figure 5
Kaplan-Meier survival within 5 years conditional on survival to 1 year by era (January 1996-June 2013).
Figure 6
Figure 6
Kaplan-Meier survival within 5-years conditional on survival to 1 year by recipient age and era (transplants: January 1996-June 2013). (slide 26)
Figure 7
Figure 7
Kaplan-Meier survival within 5-years conditional on survival to 1 year by recipient diagnosis and era (transplants: January 1996-June 2013). (slide 27)
Figure 8
Figure 8
Freedom from CAV conditional on survival to discharge by era (transplants: January 1996-June 2013).
Figure 9
Figure 9
Statistically significant categorical risk factors for 1-year mortality with 95% confidence limits (January 2000-June 2017, n = 9,376).
Figure 10
Figure 10
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by recipient age (January 2000-June 2017; n = 9,376).
Figure 11
Figure 11
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by recipient (A) glomerular filtration rate (GFR) and (B) bilirubin (January 2000-June 2017; n = 9,376). GFR was estimated using the modified Schwartz formula.
Figure 12
Figure 12
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by PRA (January 2000-June 2017; n = 9,376).
Figure 13
Figure 13
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by ischemic time (January 2000-June 2017; n = 9,376).
Figure 14
Figure 14
Multivariable hazard ratio plot for 1-year mortality with 95% confidence limits, by center volume in the previous 3 years (January 2000-June 2017; n = 9,376).
Figure 15
Figure 15
Statistically significant categorical risk factors for 5-year mortality conditional on survival to 1 year with 95% confidence limits (January 1996-June 2013; n = 7,022).
Figure 16
Figure 16
Multivariable hazard ratio plot for 5-year mortality conditional on survival to 1 year with 95% confidence limits, by recipient age (January 1996-June 2013; n = 7,022).
Figure 17
Figure 17
Multivariable hazard ratio plot for 5-year mortality conditional on survival to one year with 95% confidence limits, by recipient PRA (January 1996-June 2013; n = 7,022).
Figure 18
Figure 18
Statistically significant categorical risk factors for CAV conditional on survival to discharge with 95% confidence limits (January 1996-June 2013; n = 4,455).
Figure 19
Figure 19
Multivariable hazard ratio plot for 5-year CAV conditional on survival to discharge with 95% confidence limits, by recipient age (January 1996-June 2013; n = 4,455).
See this image and copyright information in PMC

References

    1. Rossano JW, Singh TP, Cherikh WS, et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: twenty-second pediatric heart transplantation report 2019; focus theme: donor and recipient size match. J Heart Lung Transplant 2019;38:1028–41. - PMC - PubMed
    1. Ohye RG, Sleeper LA, Mahony L, et al. Comparison of shunt types in the Norwood procedure for single-ventricle lesions. N Engl J Med 2010;362:1980–92. - PMC - PubMed
    1. Morales DLS, Adachi I, Peng DM, et al. Fourth annual pediatric interagency registry for mechanical circulatory support (pedimacs) report. Ann Thorac Surg 2020;110:1819–31. - PubMed
    1. Singh TP, Hsich E, Cherikh WS, et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: 23rd pediatric heart transplantation report 2020; focus on deceased donor characteristics. J Heart Lung Transplant 2020;39:1028–37. - PMC - PubMed
    1. Steele JM, Preminger TJ, Erenberg FG, et al. Obesity trends in children, adolescents, and young adults with congenital heart disease. Congenit Heart Dis 2019;14:517–24. - PubMed

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