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. 1978 Feb;19(2):481-5.
doi: 10.1128/iai.19.2.481-485.1978.

Chicken embryo model for type III group B beta-hemolytic streptococcal septicemia

J Tieffenberg, L Vogel, R R Kretschmer, D Padnos, S P Gotoff

Chicken embryo model for type III group B beta-hemolytic streptococcal septicemia

J Tieffenberg et al. Infect Immun. 1978 Feb.

Abstract

A lethal septicemia was induced in 11- and 12-day-old chicken embryos with intravenous inoculation of relatively small numbers of a clinical isolate (GBBHS-III-Bell) or a reference strain (GBBHS-III-D136-C) of group B beta-hemolytic streptococci (GBBHS). GBBHS-III-Bell was more virulent than GBBHS-III-D136-C, and 11-day-old chicken embryos were more susceptible than 12-day-old chicken embryos. Type-specific rabbit antisera protected the embryos from bacterial challenge, and this protective effect was absorbed with homologous but not heterologous GBBHS strains. A heterologous antiserum and normal rabbit sera provided some protection, which could be absorbed with either homologous or heterologous GBBHS strains. The chicken embryo is a suitable animal model for the study of infection and immunity with GBBHS type III.

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References

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