There is an inverse relationship between the presence of significant endoscopic findings and the amount of diazepam required to obtain adequate sedation in upper endoscopy

Abstract

A retrospective study was done in order to validate our observation that patients who require large doses of diazepam for sedation for upper endoscopy usually have less significant pathological findings than those who receive smaller, most of the patients (70%) who had significant endoscopic findings required 20 mg of diazepam or less. This was in contrast to patients requiring large doses of diazepam greater than 20 mg, who only had significant findings in 26.7% of the cases.