Current advances in transfusion medicine 2020: A critical review of selected topics by the AABB Clinical Transfusion Medicine Committee

Elizabeth S Allen¹, Claudia S Cohn², Sara Bakhtary³, Nancy M Dunbar⁴, Thomas Gniadek⁵, Courtney K Hopkins⁶, Jessica Jacobson⁷, Parvez M Lokhandwala^{8

9}, Ryan A Metcalf¹⁰, Colin Murphy¹¹, Micah T Prochaska¹², Jay S Raval¹³, Hua Shan¹⁴, Emily K Storch¹⁵, Monica B Pagano¹⁶

Affiliations

¹ Department of Pathology, University of California San Diego, La Jolla, California, USA.
² Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
³ Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
⁴ Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
⁵ Department of Pathology, NorthShore University Health System, Chicago, Illinois, USA.
⁶ Vitalant, Scottsdale, Arizona, USA.
⁷ Department of Pathology, New York University Grossman School of Medicine, New York, New York, USA.
⁸ American Red Cross, Biomedical Services, Baltimore, Maryland, USA.
⁹ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
¹⁰ Clinical Pathology Division, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
¹¹ Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
¹² Department of Medicine, University of Chicago, Chicago, Illinois, USA.
¹³ Department of Pathology, University of New Mexico, Albuquerque, New Mexico, USA.
¹⁴ Department of Pathology, Stanford University, Stanford, California, USA.
¹⁵ Office of Blood Research and Review, Food and Drug Administration, Silver Spring, Maryland, USA.
¹⁶ Transfusion Medicine Division, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.

PMID: 34423446
PMCID: PMC8630708
DOI: 10.1111/trf.16625

Review

Current advances in transfusion medicine 2020: A critical review of selected topics by the AABB Clinical Transfusion Medicine Committee

Elizabeth S Allen et al. Transfusion. 2021 Sep.

. 2021 Sep;61(9):2756-2767.

doi: 10.1111/trf.16625. Epub 2021 Aug 22.

Authors

Affiliations

¹ Department of Pathology, University of California San Diego, La Jolla, California, USA.
² Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
³ Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
⁴ Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
⁵ Department of Pathology, NorthShore University Health System, Chicago, Illinois, USA.
⁶ Vitalant, Scottsdale, Arizona, USA.
⁷ Department of Pathology, New York University Grossman School of Medicine, New York, New York, USA.
⁸ American Red Cross, Biomedical Services, Baltimore, Maryland, USA.
⁹ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
¹⁰ Clinical Pathology Division, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
¹¹ Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
¹² Department of Medicine, University of Chicago, Chicago, Illinois, USA.
¹³ Department of Pathology, University of New Mexico, Albuquerque, New Mexico, USA.
¹⁴ Department of Pathology, Stanford University, Stanford, California, USA.
¹⁵ Office of Blood Research and Review, Food and Drug Administration, Silver Spring, Maryland, USA.
¹⁶ Transfusion Medicine Division, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.

PMID: 34423446
PMCID: PMC8630708
DOI: 10.1111/trf.16625

Abstract

Background: The AABB Clinical Transfusion Medicine Committee (CTMC) compiles an annual synopsis of the published literature covering important developments in the field of transfusion medicine (TM), which has been made available as a manuscript published in Transfusion since 2018.

Methods: CTMC committee members reviewed original manuscripts including TM-related topics published electronically (ahead) or in print from December 2019 to December 2020. The selection of topics and manuscripts was discussed at committee meetings and chosen based on relevance and originality. Next, committee members worked in pairs to create a synopsis of each topic, which was then reviewed by two additional committee members. The first and senior authors of this manuscript assembled the final manuscript. Although this synopsis is extensive, it is not exhaustive, and some papers may have been excluded or missed.

Results: The following topics are included: COVID-19 effects on the blood supply and regulatory landscape, COVID convalescent plasma, adult transfusion practices, whole blood, molecular immunohematology, pediatric TM, cellular therapy, and apheresis medicine.

Conclusions: This synopsis provides easy access to relevant topics and may be useful as an educational tool.

Keywords: cellular therapy; therapeutic apheresis; transfusion practices (adult).

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Conflict of interest statement

CONFLICT OF INTEREST

CSC has disclosed professional relationships with Grifols, Terumo BCT, and Instrumentation Laboratory. NMD has disclosed financial relationship with Verax Biomedical. TG has disclosed professional relationship with Fresenius Kabi. JSR has disclosed financial relationships with Terumo BCT and Sanofi Genzyme. ESA, SB, CKH, JJ, PML, RAM, CM, MTP, HS, EKS, and MBP have disclosed no conflicts of interest.

References

1. World Health Organization. Listings of WHO's response to COVID-19. https://www.who.int/news/item/29-06-2020-covidtimeline. Accessed 25 Mar 2021.
1. Pagano MB, Hess JR, Tsang HC, Staley E, Gernsheimer T, Sen N, et al. Prepare to adapt: blood supply and transfusion support during the first 2 weeks of the 2019 novel coronavirus (COVID-19) pandemic affecting Washington State. Transfusion. 2020;60:908–11. - PubMed
1. Food & Drug Administration. Blood guidances. https://www.fda.gov/vaccines-blood-biologics/biologics-guidances/blood-g.... Accessed 22 Jan 2021.
1. Food & Drug Administration. Alternative procedures for blood and blood components during the COVID-19 public health emergency. https://www.fda.gov/regulatory-information/search-fda-guidance-documents.... Accessed 22 Jan 2021.
1. Food & Drug Administration. Revised recommendations for reducing the risk of human immunodeficiency virus transmission by blood and blood products https://www.fda.gov/regulatory-information/search-fda-guidance-documents.... Accessed 22 Jan 2021.

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Current advances in transfusion medicine 2020: A critical review of selected topics by the AABB Clinical Transfusion Medicine Committee

Affiliations

Current advances in transfusion medicine 2020: A critical review of selected topics by the AABB Clinical Transfusion Medicine Committee

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources