Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021;27(9):2475-2479.
doi: 10.3201/eid2709.210456.

Gram-Negative Bacteria Harboring Multiple Carbapenemase Genes, United States, 2012-2019

Gram-Negative Bacteria Harboring Multiple Carbapenemase Genes, United States, 2012-2019

D Cal Ham et al. Emerg Infect Dis. 2021.

Abstract

Reports of organisms harboring multiple carbapenemase genes have increased since 2010. During October 2012-April 2019, the Centers for Disease Control and Prevention documented 151 of these isolates from 100 patients in the United States. Possible risk factors included recent history of international travel, international inpatient healthcare, and solid organ or bone marrow transplantation.

Keywords: AMR; Acinetobacter baumannii; Enterobacteriaceae; Pseudomonas; United States; antimicrobial resistance; carbapenem-resistant Enterobacterales; carbapenemase; carbapenems; drug resistance; resistance genes.

PubMed Disclaimer

References

    1. Centers for Disease Control and Prevention. Biggest threats and data: 2019 AR threats report. 2019 [cited 2020 Oct 7]. https://www.cdc.gov/drugresistance/biggest-threats.html
    1. Doi Y, O’Hara JA, Lando JF, Querry AM, Townsend BM, Pasculle AW, et al. Co-production of NDM-1 and OXA-232 by Klebsiella pneumoniae. Emerg Infect Dis. 2014;20:163–5. 10.3201/eid2001.130904 - DOI - PMC - PubMed
    1. Jhang J, Wang HY, Yoo G, Hwang GY, Uh Y, Yoon KJ. NDM-5 and OXA-48 co-producing uropathogenic Escherichia coli isolate: first case in Korea. Ann Lab Med. 2018;38:277–9. 10.3343/alm.2018.38.3.277 - DOI - PMC - PubMed
    1. Lyman M, Walters M, Lonsway D, Rasheed K, Limbago B, Kallen A. Notes from the field: carbapenem-resistant Enterobacteriaceae producing OXA-48-like carbapenemases—United States, 2010–2015. MMWR Morb Mortal Wkly Rep. 2015;64:1315–6. 10.15585/mmwr.mm6447a3 - DOI - PubMed
    1. Meletis G, Chatzidimitriou D, Malisiovas N. Double- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade. Eur J Clin Microbiol Infect Dis. 2015;34:1487–93. 10.1007/s10096-015-2379-9 - DOI - PubMed

LinkOut - more resources