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Review
. 2021 Dec 1;96(12):1655-1665.
doi: 10.1002/ajh.26328. Epub 2021 Sep 4.

Severe thrombocytopenia and microangiopathic hemolytic anemia in pregnancy: A guide for the consulting hematologist

Juliana Perez Botero  1   2 , Jessica A Reese  3 , James N George  3   4 , Jennifer J McIntosh  5
Affiliations
Review

Severe thrombocytopenia and microangiopathic hemolytic anemia in pregnancy: A guide for the consulting hematologist

Juliana Perez Botero et al. Am J Hematol. .

Abstract

A hematologist receives a call from a maternal-fetal medicine (MFM) physician about a previously healthy patient who became ill at 25 weeks' gestation. Her mental status is deteriorating. There are signs of fetal distress. Platelet count and hemoglobin are falling. The MFM physician is considering the hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome. For the hematologist, everything seems unfamiliar. Our goal is to provide hematologists with the fundamental knowledge required for understanding and managing these patients who become suddenly and seriously ill during pregnancy and in whom thrombocytopenia and microangiopathic hemolytic anemia are part of their presentation.

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Figures

FIGURE 1
FIGURE 1
Distinguishing PE/HELLP syndrome from TTP and other causes of severe thrombocytopenia and MAHA
See this image and copyright information in PMC

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