Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Oct;17(10):1053-1057.
doi: 10.1080/1744666X.2021.1971973. Epub 2021 Sep 6.

The GLP-1 receptor in airway inflammation in asthma: a promising novel target?

Ashley Y Wu  1 , R Stokes Peebles  1   2   3   4
Affiliations
Editorial

The GLP-1 receptor in airway inflammation in asthma: a promising novel target?

Ashley Y Wu et al. Expert Rev Clin Immunol. 2021 Oct.
No abstract available

Keywords: Asthma; GLP-1; IL-33; ILC2.

PubMed Disclaimer

Conflict of interest statement

Declaration of Interest:

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed

Figures

Figure 1.
Figure 1.
Various mechanisms have been proposed for the role of GLP-1R agonists in reducing inflammatory airway disease, including airway modification with increased surfactant production and decreased mucus secretion, decreased Type 2 inflammatory signaling, and increased smooth muscle relaxation.
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020. Atlanta, GA: Centers for Disease Control and Prevention, U.S. Dept of Health and Human Services. 2020.
    1. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132:2131–2157. - PubMed
    1. Pyke C, Heller RS, Kirk RK, et al. GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody. Endocrinology. 2014;155:1280–1290. - PubMed
    1. Viby N-E, Isidor MS, Buggeskov KB, et al. Glucagon-like peptide-1 (GLP-1) reduces mortality and improves lung function in a model of experimental obstructive lung disease in female mice. Endocrinology. 2013;154:4503–4511. - PubMed
    1. Hur J, Kang JY, Kim YK, et al. Glucagon-like peptide 1 receptor (GLP-1R) agonist relieved asthmatic airway inflammation via suppression of NLRP3 inflammasome activation in obese asthma mice model. Pulm Pharmacol Ther. 2021;67:102003. - PubMed

Publication types