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Clinical Trial
. 2021 Oct;129(8):770-781.
doi: 10.1161/CIRCRESAHA.121.318965. Epub 2021 Aug 25.

Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health

Brian T Joyce  1   2 , Tao Gao  1   2 , Yinan Zheng  1   2 , Jiantao Ma  3   4 , Shih-Jen Hwang  3   4 , Lei Liu  5 , Drew Nannini  1   2 , Steve Horvath  6 , Ake T Lu  6 , Norrina Bai Allen  2 , David R Jacobs Jr  7 , Myron Gross  7 , Amy Krefman  2 , Hongyan Ning  2 , Kiang Liu  2 , Cora E Lewis  8 , Pamela J Schreiner  9 , Stephen Sidney  10 , James M Shikany  8 , Daniel Levy  3   4 , Philip Greenland  2 , Lifang Hou #  1   2 , Donald Lloyd-Jones #  2
Affiliations
Clinical Trial

Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health

Brian T Joyce et al. Circ Res. 2021 Oct.

Abstract

[Figure: see text].

Keywords: DNA methylation; blood pressure; cardiovascular diseases; humans; young adult.

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Figures

Figure 1:
Figure 1:. Study design.
In CARDIA we examined DNA methylation collected at two time points (Y15 and Y20), then combined models using generalized estimating equations (GEEs). We then validated our findings in FHS, and used GEE models to conduct stratified and sensitivity analyses. Mediation analyses (not pictured) modeled CVH and GrimAA from each cohort and time point separately. A similar model structure was used to analyze IEAA and EEAA.
Figure 2:
Figure 2:
Mediation Analyses in CARDIA and FHS. Figure illustrates study design in CARDIA. In CARDIA only, FDR values were calculated from all tests of clinical CVH and full CVH separately.
See this image and copyright information in PMC

References

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