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Review
. 2021 Sep 15;81(18):4673-4675.
doi: 10.1158/0008-5472.CAN-21-1407. Epub 2021 Aug 24.

Translating the Science of Cancer Dormancy to the Clinic

Julio A Aguirre-Ghiso  1   2   3   4   5
Affiliations
Review

Translating the Science of Cancer Dormancy to the Clinic

Julio A Aguirre-Ghiso. Cancer Res. .

Abstract

The paradigm of metastasis has been significantly remodeled by the incorporation of cancer dormancy as a mechanism to explain long-term remission intervals followed by relapse. There is overall consensus on the potential impact of better understanding dormancy. Key cancer-cell autonomous and microenvironmental mechanisms might explain this biology and, in turn, the timing of metastasis. However, the approach and feasibility to apply this biology to clinical trials has been controversial. The discussion here provides insight into how these controversies are being resolved by the development of active clinical trials, thus bringing to reality opportunities to target cancer dormancy.

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Conflict of interest statement

Conflict of Interest Statement:

JAAG is a scientific co-founder of, scientific advisory board member and equity owner in HiberCell LLC and receives financial compensation as a consultant for HiberCell, a Mount Sinai spin-off company focused on therapeutics that prevent or delay cancer recurrence.

References

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