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Case Reports
. 2021 Aug 17;9(6):e04355.
doi: 10.1002/ccr3.4355. eCollection 2021 Jun.

Rosette-forming glioneuronal tumor of the fourth ventricle; A case report and review of the literature

Tadeja Verbančič  1 , Janez Ravnik  2 , Rajko Kavalar  1
Affiliations
Case Reports

Rosette-forming glioneuronal tumor of the fourth ventricle; A case report and review of the literature

Tadeja Verbančič et al. Clin Case Rep. .

Abstract

Despite mostly indolent course and favorable postoperative outcome long-term follow-up studies are needed to identify the most appropriate therapeutic strategies to minimize surgical morbidity and neurologic injury in patients with RGNT.

Keywords: Rosette‐forming glioneuronal tumor; frozen section diagnostics; histology; symptoms; treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Imaging features of the RGNT. A, CT‐scan with contrast. A mildly hypodense mass lesion (asterisk) in the fourth ventricle measuring 30 × 40 × 40 mm. There was no enhancement after contrast administration. B, MRI, T2‐weighted image. Well‐demarcated, abundant tumor in the fourth ventricle with surrounding edema
FIGURE 2
FIGURE 2
Frozen section of the RGNT. A, Moderately cellular (asterisk) and hypocellular (arrows) areas (H&E × 100). B, Moderately cellular tumor area with implied circle‐like arrangement of the small, bland and uniform nuclei (arrows) (H&E × 200)
FIGURE 3
FIGURE 3
Histopathological features of the RGNT. A, Loose hypocellular astrocytic component (asterisk) with rare microcalcifications (arrow). (H&E, ×200). B, Neurocytes with small, round, regular nuclei with speckled chromatin and scant cytoplasm forming rosettes (arrows) with central eosinophilic neuropil material. (H&E, ×400)
FIGURE 4
FIGURE 4
Immunohistochemistry confirms the presence of the A, glial (GFAP—polyclonal, DAKO, ×200) and B, neuronal (Synaptophysin—clone 27G12, Biocare Medical, ×200) differentiation in the tumor
See this image and copyright information in PMC

References

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