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Case Reports
. 2021 Jul 20;13(7):e16509.
doi: 10.7759/cureus.16509. eCollection 2021 Jul.

Pathology of Seminoma Coinciding With Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia

Katherine M Bui  1 , Hailing Zhang  1 , Bernadette M Boac  2 , Monica S Chatwal  3 , Jasreman Dhillon  1
Affiliations
Case Reports

Pathology of Seminoma Coinciding With Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia

Katherine M Bui et al. Cureus. .

Abstract

We present the case of a 71-year-old male with an incidental diagnosis of seminoma coinciding with small lymphocytic lymphoma/chronic lymphocytic leukemia in the retroperitoneum. This case report illustrates the cytology, histology, immunohistochemistry, flow cytometry, and fluorescence in situ hybridization features of this exceptional case and sheds light on the importance of a collaborative multidisciplinary team in delivering quality patient care.

Keywords: chronic lymphocytic leukemia; diagnosis; oncology; pathology; seminoma; small lymphocytic lymphoma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Baseline radiology.
Baseline radiology of pathologic lesions, (A) right paratracheal mass and (B) left retroperitoneal mass, on CT correlates of PET imaging. CT, computed tomography; PET, positron emission tomography.
Figure 2
Figure 2. Flow cytometry.
(A) Monoclonal kappa light chain-restricted B-cells detected, (B) co-expressing CD5. FITC, fluorescein isothiocyanate.
Figure 3
Figure 3. Seminoma with a background of SLL/CLL cytology.
Large seminoma cells with a “tigroid” matrix and background of SLL cells (Diff-Quick stain, x400 magnification). SLL, small lymphocytic lymphoma; CLL, chronic lymphocytic leukemia.
Figure 4
Figure 4. SLL/CLL histology.
(A) The biopsy involved by SLL/CLL showing sheets of small lymphocytes with scant cytoplasm and clumped chromatin (hematoxylin and eosin stain, x400 magnification). Immunohistochemistry showing positive staining with (B) CD20, (C) CD5, and (D) LEF-1 (x200 magnification). SLL, small lymphocytic lymphoma; CLL, chronic lymphocytic leukemia.
Figure 5
Figure 5. Histology of seminoma with SLL/CLL.
(A) Small groups of a second population of neoplastic cells with a round nucleus, prominent nucleolus, and moderate amount of clear cytoplasm consistent with seminoma admixed with SLL/CLL (hematoxylin and eosin stain, x200 magnification). Immunohistochemistry showing positive staining of the large atypical seminoma cells with (B) OCT4, (C) CD117, and (D) PLAP (x100 magnification). SLL, small lymphocytic lymphoma; CLL, chronic lymphocytic leukemia.
Figure 6
Figure 6. Post-treatment radiology.
Post-treatment radiology of pathologic lesions, (A) right paratracheal mass and (B) left retroperitoneal mass, on CT correlates of PET. CT, computed tomography; PET, positron emission tomography.
See this image and copyright information in PMC

References

    1. Cancer statistics, 2021. Siegel RL, Miller KD, Fuchs HE, Jemal A. CA Cancer J Clin. 2021;71:7–33. - PubMed
    1. Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015. Zelenetz AD, Gordon LI, Wierda WG, et al. J Natl Compr Canc Netw. 2015;13:326–362. - PMC - PubMed
    1. Gonadal and extragonadal germ cell tumours in the United States, 1973-2007. Stang A, Trabert B, Wentzensen N, Cook MB, Rusner C, Oosterhuis JW, McGlynn KA. Int J Androl. 2012;35:616–625. - PMC - PubMed
    1. Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases. Krag Jacobsen G, Barlebo H, Olsen J, Schultz HP, Starklint H, Søgaard H, Vaeth M. Acta Radiol Oncol. 1984;23:239–247. - PubMed
    1. The differential diagnosis of testicular germ cell tumors in theory and practice. A critical analysis of two major systems of classification and review of 389 cases. von Hochstetter AR, Hedinger CE. Virchows Arch A Pathol Anat Histol. 1982;396:247–277. - PubMed

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