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Review
. 2021 Jul 20;13(7):e16522.
doi: 10.7759/cureus.16522. eCollection 2021 Jul.

Off-Label Use of Teriparatide in Spine

Panagiotis Drakopoulos  1   2 , Dimitrios A Flevas  3 , Ioannis P Galanopoulos  2 , Panagiotis Lepetsos  4 , Christos Zafeiris  5
Affiliations
Review

Off-Label Use of Teriparatide in Spine

Panagiotis Drakopoulos et al. Cureus. .

Abstract

Teriparatide belongs to osteo-anabolic compounds and has been used in recent years to treat patients with osteoporosis, with the benefits of increased bone density. Its osteo-anabolic action has led to the investigation of the use of teriparatide for the improvement of bone quality. Apart from the enhancement of fracture union, teriparatide has been extensively studied in the promotion of fusion rate after spinal fusion. This study summarizes the preclinical and clinical results of the off-label use of teriparatide in the spine, and specifically its intermittent administration after instrumented spinal arthrodesis along with its impact on the spinal bone quality and spinal bone mineral density.

Keywords: off-label; parathyroid hormone; spinal fusion; spine; teriparatide.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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