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Editorial
. 2021 Aug 9;34(8):779-782.
doi: 10.1093/ajh/hpab085.

COVID-19 and ROS Storm: What is the Forecast for Hypertension

Amanda A de Oliveira  1 , Fernanda Priviero  2 , Victor V Lima  3 , R Clinton Webb  2 , Kenia P Nunes  1
Affiliations
Editorial

COVID-19 and ROS Storm: What is the Forecast for Hypertension

Amanda A de Oliveira et al. Am J Hypertens. .
No abstract available

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Figures

Graphical Abstract
Graphical Abstract
Figure 1.
Figure 1.
COVID-19 and ROS storm in hypertension. The mechanisms triggering increased oxidative stress are pre-activated in hypertension. Consequently, the release of ROS is most likely intensified in the vasculature of COVID-19 hypertensive patients, giving rise to a dysregulated response, culminating in a ROS storm. This deranged response exacerbates the vascular damage, contributing to disease severity. Abbreviations: ACE2, angiotensin converting enzyme 2; AngII, angiotensin II; Ang(1–7), angiotensin (1–7); AT1r, angiotensin II receptor type 1; Brad., bradykinin; BR, bradykinin receptor; DAMPs, damage-associated molecular patterns; eNOS, endothelial nitric oxide synthase; IFNs, interferons; IL-6, interleukin 6; IRFs, interferon regulatory factor; MASR, MAS receptor; NADPH, nicotinamide adenine dinucleotide phosphate; Nrf2, nuclear factor erythroid 2–related factor 2; NF-κB, nuclear factor-κB; PAMPs, pathogen-associated molecular patterns; ROS, reactive oxygen species; TLRs, toll-like receptors; TNF-α, tumor necrosis factor-α.
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References

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