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. 2021 Nov;31(6):779-787.
doi: 10.1111/vec.13099. Epub 2021 Aug 25.

Assessment of the impact of age and of blood-derived inflammatory markers in horses with colitis

Sophie E Sage  1 , Daniela Bedenice  1 , Caroline A McKinney  1 , Alicia E Long  1 , Ana Pacheco  1 , Bettina Wagner  2 , Melissa R Mazan  1 , Mary Rose Paradis  1
Affiliations

Assessment of the impact of age and of blood-derived inflammatory markers in horses with colitis

Sophie E Sage et al. J Vet Emerg Crit Care (San Antonio). 2021 Nov.

Abstract

Objectives: To determine the impact of age on survival in horses with colitis and to elucidate whether a lower type-1/type-2 cytokine ratio or an exaggerated inflammatory state contribute to reduced survival in aged horses.

Design: Part 1: Retrospective cohort analysis. Part 2: Analytic observational study.

Animals: Part 1: One hundred twenty-four adult horses with colitis. Part 2: Twenty-nine adult horses with new diarrhea onset while hospitalized.

Measurements and main results: Part 1: Patient signalment, select clinicopathological data, diagnoses, treatment, hospitalization length, and invoice were compared between survivors (n = 101) and nonsurvivors (n = 23). Only age and plasma transfusion retained statistical significance in the final multivariate outcome model, with 8.5 times lower odds of survival in transfused horses (95% confidence interval [CI], 2.6-27.2%). Additionally, the likelihood of nonsurvival increased by 11.8% (95% CI, 4-20.2%) for every year the horse aged (P = 0.002). Similarly, geriatric horses (≥20 years) were 15.2 times more likely to die than young-adults (2-12 years, P = 0.03), independent of financial investment, documented comorbidities, and duration of hospitalization. Part 2: Select cytokine analyses were performed on serum collected from hospitalized horses within 1 hour of diarrhea onset (T0) and 6 hours later. At T0, all recorded clinicopathological variables were comparable between geriatric and young-adult horses, suggesting a similar degree of systemic illness. The median concentration of type-2 cytokines interleukin-4 and interleukin-10, and type-1 cytokine interferon-γ did not differ between age groups. Inflammatory cytokines interleukin-6 and tumor necrosis factor-α were significantly higher in geriatric compared to young-adult horses at both sampling time points.

Conclusions: Outcome of colitis was less favorable in aging horses and patients receiving a plasma transfusion. Although an exaggerated inflammatory state, based on increased interleukin-6 and tumor necrosis factor-α concentrations, in geriatric horses may contribute to reduced survival, a lower type-1/type-2 cytokines ratio was not identified in our geriatric population.

Keywords: colic; colitis; geriatric horse; inflammatory state.

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References

REFERENCES

    1. Animal and Plant Health Inspection Service. Age-related trends in demographics of equids in the United States. 2018. p. 1-3. Available at https://www.aphis.usda.gov/animal_health/nahms/equine/downloads/equine15.... Accessed March 3, 2019.
    1. Paradis MR. Demographics of health and disease in the geriatric horse. Vet Clin Equine. 2002;18(March):391-401.
    1. Khanafer N, Barbut F, Eckert C, et al. Factors predictive of severe Clostridium difficile infection depend on the definition used. Anaerobe. 2016;37:43-48.
    1. Sprung CL, Artigas A, Kesecioglu J, et al. The Eldicus prospective, observational study of triage decision making in European intensive care units. Part II: intensive care benefit for the elderly. Critical Care Medicine. 2012;40(1):132-138.
    1. Cohen ND, Woods AM. Characteristics and risk factors for failure of horses with acute diarrhea to survive: 122 cases (1990-1996). Journal of the American Veterinary Medical Association. 1999;214(3):382-390. Feb 1.

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