Two cases of T cell lymphoma following Piggybac-mediated CAR T cell therapy
- PMID: 34433080
- PMCID: PMC8417502
- DOI: 10.1016/j.ymthe.2021.08.013
Two cases of T cell lymphoma following Piggybac-mediated CAR T cell therapy
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
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Comment on
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Investigation of product-derived lymphoma following infusion of piggyBac-modified CD19 chimeric antigen receptor T cells.Blood. 2021 Oct 21;138(16):1391-1405. doi: 10.1182/blood.2021010858. Blood. 2021. PMID: 33974080 Free PMC article. Clinical Trial.
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Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells.Blood. 2021 Oct 21;138(16):1504-1509. doi: 10.1182/blood.2021010813. Blood. 2021. PMID: 34010392 Clinical Trial. No abstract available.
References
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- Micklethwaite K.P., Gowrishankar K., Gloss B.S., Li Z., Street J.A., Moezzi L., Mach M.A., Sutrave G., Clancy L.E., Bishop D.C. Investigation of product derived lymphoma following infusion of piggyBac modified CD19 chimeric antigen receptor T-cells. Blood. 2021 doi: 10.1182/blood.2021010858. Published online May 11, 2021. - DOI - PMC - PubMed
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- Bishop D.C., Clancy L.E., Simms R., Burgess J., Mathew G., Moezzi L., Street, J.A., Sutrave, G., Atkins, E., McGuire, H.M. Development of CAR T-cell lymphoma in two of ten patients effectively treated with piggyBac modified CD19 CAR T-cells. Blood. 2021 doi: 10.1182/blood.2021010813. Published online May 19, 2021. - DOI - PubMed
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- Newrzela S., Al-Ghaili N., Heinrich T., Petkova M., Hartmann S., Rengstl B., Kumar A., Jäck H.M., Gerdes S., Roeder I. T-cell receptor diversity prevents T-cell lymphoma development. Leukemia. 2012;26:2499–2507. - PubMed
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