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Review
. 2021 Aug 11:2021:9919422.
doi: 10.1155/2021/9919422. eCollection 2021.

Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy

Qian Luo  1   2   3   4 , Honghu Li  1   2   3   4 , Wei Shan  1   2   3   4 , Cong Wei  1   2   3   4 , Yan Long  1   2   3   4 , Shuyang Cai  1   2   3   4 , Xiangjun Zeng  1   2   3   4 , Xue Li  1   2   3   4 , Yulin Xu  1   2   3   4 , Xiaoxiao Xu  1   2   3   4 , Yi Luo  1   2   3   4 , Pengxu Qian  1   2   3   4   5   6 , He Huang  1   2   3   4   5
Affiliations
Review

Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy

Qian Luo et al. Stem Cells Int. .

Abstract

Widely known for self-renewal and multilineage differentiation, stem cells can be differentiated into all specialized tissues and cells in the body. In the past few years, a number of researchers have focused on deriving hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) as alternative sources for clinic. Existing findings demonstrated that it is feasible to obtain HSCs and certain mature blood lineages from PSCs, except for several issues to be addressed. This short review outlines the technologies used for hematopoietic differentiation in recent years. In addition, the therapeutic value of PSCs as a potential source of various blood cells is also discussed as well as its challenges and directions in future clinical applications.

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Conflict of interest statement

The authors declared that they had no conflicts of interest.

Figures

Figure 1
Figure 1
Profile of the sites, timing, and emergence of various blood cells during hematopoietic ontogeny.
Figure 2
Figure 2
Overview of the current approaches for hematopoietic stem cells differentiation from pluripotent stem cells in vitro and the potential of downstream cells for future clinical application. EHT: endothelial to hematopoietic transition.
Figure 3
Figure 3
The method of hematopoietic differentiation in vivo.
See this image and copyright information in PMC

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