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. 2021 Jul 31;19(8):438.
doi: 10.3390/md19080438.

New Cytotoxic Cytochalasans from a Plant-Associated Fungus Chaetomium globosum kz-19

Tantan Li  1   2 , Yun Wang  1 , Li Li  3 , Mengyue Tang  1   4 , Qinghong Meng  1   2 , Cun Zhang  1 , Erbing Hua  2 , Yuehu Pei  4 , Yi Sun  1
Affiliations

New Cytotoxic Cytochalasans from a Plant-Associated Fungus Chaetomium globosum kz-19

Tantan Li et al. Mar Drugs. .

Abstract

Four new cytochalasans, phychaetoglobins A-D (1-4), together with twelve known cytochalasans (5-16), were isolated from a mangrove-associated fungus Chaetomium globosum kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established by application of Mosher's method. Compounds 4-8 exhibited moderate cytotoxicities against A549 and HeLa cell lines with the IC50 values less than 20 μM.

Keywords: Chaetomium globosum kz-19; cytochalasans; cytotoxicity; endophytic fungus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of compounds 1–16.
Figure 2
Figure 2
(a) Key HMBC and 1H-1H COSY correlations of 1 and 2; (b) Key NOESY correlations of 1 and 2; (c) Experimental and calculated ECD of 1 and 2 (1a, 1b and 2a, 2b) in MeOH.
Figure 3
Figure 3
Values of ΔδS-δR of the MTPA esters of 2 (in DMSO-d6).
See this image and copyright information in PMC

References

    1. Scheriach K., Boettger D., Remme N., Hertweck C. The chemistry and biology cytochalasans. Nat. Prod. Rep. 2010;27:869–886. doi: 10.1039/b903913a. - DOI - PubMed
    1. Qi J., Jiang L., Zhao P., Chen H., Jia X., Zhao L., Dai H., Hu J., Liu C., Shim S.H., et al. Chaetoglobosins and azaphilones from Chaetomium globosum associated with Apostichopus japonicus. Appl. Microbiol. Biotechnol. 2020;104:1545–1553. doi: 10.1007/s00253-019-10308-0. - DOI - PubMed
    1. Selim K.A., Ei-Beih A.A., Abdel-Rahman T.M., Ei-Diwany A.I. Biological evaluation of endophytic fungus, Chaetomium globosum JN711454, as potential candidate for improving drug discovery. Cell Biochem. Biophys. 2014;68:67–82. doi: 10.1007/s12013-013-9695-4. - DOI - PubMed
    1. Cui C.M., Li X.M., Li C.S., Proksch P., Wang B.G. Cytoglobosins A-G, cytochalasans from a marine-derived endophytic gungus, Chaetomium globosum QEN-14. J. Nat. Prod. 2010;73:729–733. doi: 10.1021/np900569t. - DOI - PubMed
    1. Chen C., Wang J., Liu J., Zhu H., Sun B., Wang J., Zhang J., Luo Z., Yao G., Xue Y., et al. Armochaetoglobins A-J: Cytochalasan alkaloids from Chaetomium globosum TW1-1, a fungus derived from the tereestrial arthropod Armadillidium vulgare. J. Nat. Prod. 2015;78:1193–1201. doi: 10.1021/np500626x. - DOI - PubMed

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