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Review
. 2021 Aug 10;13(16):4033.
doi: 10.3390/cancers13164033.

Lung Cancer Surgery after Neoadjuvant Immunotherapy

Dirk Stefani  1 , Till Plönes  1 , Jan Viehof  1 , Kaid Darwiche  2 , Martin Stuschke  3 , Martin Schuler  4 , Clemens Aigner  1
Affiliations
Review

Lung Cancer Surgery after Neoadjuvant Immunotherapy

Dirk Stefani et al. Cancers (Basel). .

Abstract

In early-stage lung cancer, recurrences are observed even after curative resection. Neoadjuvant immunotherapy might be a promising approach to eliminate micrometastasis and to potentially reduce recurrence rates and improve survival. Early trials have shown encouraging rates of pathologic response to neoadjuvant therapy and have demonstrated that surgery can be safely performed after neoadjuvant immunotherapy with various agents and in combination with chemo-(radio)therapy. However, whether these response rates translate into improved disease-free survival rates and overall survival rates remains to be determined by ongoing phase III studies.

Keywords: lung cancer surgery; neoadjuvant immunotherapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Survival after surgical resection of lung cancer according to TNM8 stage grouping [2].
See this image and copyright information in PMC

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