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Review
. 2021 Jul 22;11(8):1084.
doi: 10.3390/biom11081084.

Pathological Roles and Clinical Usefulness of Periostin in Type 2 Inflammation and Pulmonary Fibrosis

Junya Ono  1 , Masayuki Takai  1   2 , Ayami Kamei  1 , Yoshinori Azuma  1 , Kenji Izuhara  2
Affiliations
Review

Pathological Roles and Clinical Usefulness of Periostin in Type 2 Inflammation and Pulmonary Fibrosis

Junya Ono et al. Biomolecules. .

Abstract

Periostin is known to be a useful biomarker for various diseases. In this article, we focus on allergic diseases and pulmonary fibrosis, for which we and others are now developing detection systems for periostin as a biomarker. Biomarker-based precision medicine in the management of type 2 inflammation and fibrotic diseases since heterogeneity is of utmost importance. Periostin expression is induced by type 2 cytokines (interleukin-4/-13) or transforming growth factor-β, and plays a vital role in the pathogenesis of allergic inflammation or interstitial lung disease, respectively, andits serum levels are correlated disease severity, prognosis and responsiveness to the treatment. We first summarise the importance of type 2 biomarker and then describe the pathological role of periostin in the development and progression of type 2 allergic inflammation and pulmonary fibrosis. In addition, then, we summarise the recent development of assay methods for periostin detection, and analyse the diseases in which periostin concentration is elevated in serum and local biological fluids and its usefulness as a biomarker. Furthermore, we describe recent findings of periostin as a biomarker in the use of biologics or anti-fibrotic therapy. Finally, we describe the factors that influence the change in periostin concentration under the healthy conditions.

Keywords: IL-13; biomarker; eosinophilic chronic rhinosinusitis; idiopathic pulmonary fibrosis; periostin; type 2 inflammation.

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Conflict of interest statement

Junya Ono, Masayuki Takai, Ayami Kamei and Yoshinori Azuma are employees of Shino-Test Corporation.

Figures

Figure 1
Figure 1
Schematic representation of periostin structural domains and function. FAS, Fasciclin; BMP, Bone morphogenetic protein.
Figure 2
Figure 2
Type 2 biomarkers induced by IL-4/-13. Th, T helper; IL, interleukin; FeNO, Fractional exhaled nitric oxide; TARC, Thymus and activation-regulated chemokine; SCCA2, Squamous cell carcinoma antigens.
Figure 3
Figure 3
Summary of type 2 inflammatory response related to periostin in the pathogenesis of allergic diseases. TSLP, thymic stromal lymphopoietin; IL, interleukin; Th2, T helper 2 cells; ILC2, innate lymphoid cells.
See this image and copyright information in PMC

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