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Review
. 2021 Jul 28;12(8):1154.
doi: 10.3390/genes12081154.

Circulating microRNAs from the Molecular Mechanisms to Clinical Biomarkers: A Focus on the Clear Cell Renal Cell Carcinoma

Claudia Tito  1 , Elena De Falco  2   3 , Paolo Rosa  2 , Alessia Iaiza  1 , Francesco Fazi  1 , Vincenzo Petrozza  2 , Antonella Calogero  2
Affiliations
Review

Circulating microRNAs from the Molecular Mechanisms to Clinical Biomarkers: A Focus on the Clear Cell Renal Cell Carcinoma

Claudia Tito et al. Genes (Basel). .

Abstract

microRNAs (miRNAs) are emerging as relevant molecules in cancer development and progression. MiRNAs add a post-transcriptional level of control to the regulation of gene expression. The deregulation of miRNA expression results in changing the molecular circuitry in which miRNAs are involved, leading to alterations of cell fate determination. In this review, we describe the miRNAs that are emerging as innovative molecular biomarkers from liquid biopsies, not only for diagnosis, but also for post-surgery management in cancer. We focus our attention on renal cell carcinoma, in particular highlighting the crucial role of circulating miRNAs in clear cell renal cell carcinoma (ccRCC) management. In addition, the functional deregulation of miRNA expression in ccRCC is also discussed, to underline the contribution of miRNAs to ccRCC development and progression, which may be relevant for the identification and design of innovative clinical strategies against this tumor.

Keywords: biomarkers; ccRCC; circulating miRNAs; liquid biopsies.

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Conflict of interest statement

The authors declare no conflict of interest.

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