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. 2021 Jul 30;11(8):772.
doi: 10.3390/life11080772.

Prevalence of Bladder and Bowel Dysfunction in Duchenne Muscular Dystrophy Using the Childhood Bladder and Bowel Dysfunction Questionnaire

Judith M Lionarons  1   2 , Imelda J M de Groot  3   4 , Johanna M Fock  5 , Sylvia Klinkenberg  1 , Desiree M J Vrijens  6 , Anita C E Vreugdenhil  7   8 , Evita G Medici-van den Herik  9 , Inge Cuppen  10 , Bregje Jaeger  11 , Erik H Niks  4   12 , Rinske Hoogerhuis  13 , Nicky Platte-van Attekum  13 , Frans J M Feron  14 , Catharina G Faber  1   2 , Jos G M Hendriksen  4   15 , Johan S H Vles  2
Affiliations

Prevalence of Bladder and Bowel Dysfunction in Duchenne Muscular Dystrophy Using the Childhood Bladder and Bowel Dysfunction Questionnaire

Judith M Lionarons et al. Life (Basel). .

Abstract

Introduction: Lower urinary tract symptoms (LUTS) and gastrointestinal (GI) problems are common in Duchenne muscular dystrophy (DMD), but not systematically assessed in regular care. We aimed to determine the prevalence of bladder and bowel dysfunction (BBD) in DMD patients compared with healthy controls (HC).

Methods: The Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) based on the International Rome III criteria and the International Children's Continence Society was filled out by 57 DMD patients and 56 HC. Additionally, possible associations of BBD with, for example, medication use or quality of life were evaluated in an additional questionnaire developed by experts.

Results: In 74% of patients versus 56% of HC ≥ 1 LUTS (n.s.) were reported, 68% of patients versus 39% of HC reported ≥1 bowel symptom (p = 0.002) and 53% of patients versus 30% of HC reported combined LUTS and bowel symptoms (p = 0.019). A negative impact of BBD on daily life functioning was reported by 42% of patients.

Conclusions: These data underscore that standard screening for BBD is needed and that the CBBDQ could be of added value to optimize DMD care.

Keywords: Duchenne muscular dystrophy; bladder and bowel dysfunction; constipation; lower urinary tract symptoms; urinary incontinence.

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Conflict of interest statement

The authors declare no conflict of interest. The sponsors had no role in the design, execution, interpretation, or writing of the study.

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