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Review
. 2021 Jul 21;10(8):1849.
doi: 10.3390/cells10081849.

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Daozheng Yang  1 , Gerald de Haan  1   2
Affiliations
Review

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Daozheng Yang et al. Cells. .

Abstract

Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages. The functioning of aged HSCs is impaired, including a declined repopulation capacity and myeloid and platelet-restricted differentiation. Both cell-intrinsic and microenvironmental extrinsic factors contribute to HSC aging. Recent studies highlight the emerging role of inflammation in contributing to HSC aging. In this review, we summarize the recent finding of age-associated changes of HSCs and the bone marrow niche in which they lodge, and discuss how inflammation may drive HSC aging.

Keywords: aging; hematopoietic stem cells; heterogeneity; inflammation; niche.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Age-associated changes in HSCs and their niche. Aged HSCs, with reduced repopulation potential, are dominated by myeloid/platelet-biased HSCs. HSCs’ age-associated defects are partially the consequences of age-associated changes in the niche. ↓ and ↑ represent increased and decreased activity, respectively.
See this image and copyright information in PMC

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