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. 2021 Aug 17;10(16):3641.
doi: 10.3390/jcm10163641.

Stress Echo 2030: The Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging

Eugenio Picano  1 , Quirino Ciampi  2 , Lauro Cortigiani  3 , Adelaide M Arruda-Olson  4 , Clarissa Borguezan-Daros  5 , José Luis de Castro E Silva Pretto  6   7 , Rosangela Cocchia  8 , Eduardo Bossone  8 , Elisa Merli  9 , Garvan C Kane  4 , Albert Varga  10 , Gergely Agoston  10 , Maria Chiara Scali  11 , Doralisa Morrone  12 , Iana Simova  13 , Martina Samardjieva  13 , Alla Boshchenko  14 , Tamara Ryabova  14 , Alexander Vrublevsky  14 , Attila Palinkas  15 , Eszter D Palinkas  16 , Robert Sepp  16 , Marco A R Torres  17 , Hector R Villarraga  4 , Tamara Kovačević Preradović  18 , Rodolfo Citro  19 , Miguel Amor  20 , Hugo Mosto  20 , Michael Salamè  20 , Paul Leeson  21 , Cristina Mangia  22 , Nicola Gaibazzi  23 , Domenico Tuttolomondo  23 , Costantina Prota  24 , Jesus Peteiro  25 , Caroline M Van De Heyning  26 , Antonello D'Andrea  27 , Fausto Rigo  28 , Aleksandra Nikolic  29 , Miodrag Ostojic  29 , Jorge Lowenstein  30 , Rosina Arbucci  30 , Diego M Lowenstein Haber  30 , Pablo M Merlo  30 , Karina Wierzbowska-Drabik  31 , Jaroslaw D Kasprzak  31 , Maciej Haberka  32 , Ana Cristina Camarozano  33 , Nithima Ratanasit  34 , Fabio Mori  35 , Maria Grazia D'Alfonso  35 , Luigi Tassetti  35 , Alessandra Milazzo  35 , Iacopo Olivotto  35 , Alberto Marchi  35 , Hugo Rodriguez-Zanella  36 , Angela Zagatina  37 , Ratnasari Padang  4 , Milica Dekleva  38 , Ana Djordievic-Dikic  39 , Nikola Boskovic  39 , Milorad Tesic  39 , Vojislav Giga  39 , Branko Beleslin  39 , Giovanni Di Salvo  40 , Valentina Lorenzoni  41 , Matteo Cameli  42 , Giulia Elena Mandoli  42 , Tonino Bombardini  18 , Pio Caso  27 , Jelena Celutkiene  43 , Andrea Barbieri  44 , Giovanni Benfari  45 , Ylenia Bartolacelli  46 , Alessandro Malagoli  47 , Francesca Bursi  48 , Francesca Mantovani  49 , Bruno Villari  2 , Antonello Russo  50 , Michele De Nes  1 , Clara Carpeggiani  1 , Ines Monte  51 , Federica Re  52 , Carlos Cotrim  53 , Giuseppe Bilardo  54 , Ariel K Saad  55 , Arnas Karuzas  56 , Dovydas Matuliauskas  56 , Paolo Colonna  57   58 , Francesco Antonini-Canterin  58   59 , Mauro Pepi  58   60 , Patricia A Pellikka  4 , The Stress Echo Study Group Of The Italian Society Of Echocardiography And Cardiovascular Imaging Siecvi
Affiliations

Stress Echo 2030: The Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging

Eugenio Picano et al. J Clin Med. .

Abstract

With stress echo (SE) 2020 study, a new standard of practice in stress imaging was developed and disseminated: the ABCDE protocol for functional testing within and beyond CAD. ABCDE protocol was the fruit of SE 2020, and is the seed of SE 2030, which is articulated in 12 projects: 1-SE in coronary artery disease (SECAD); 2-SE in diastolic heart failure (SEDIA); 3-SE in hypertrophic cardiomyopathy (SEHCA); 4-SE post-chest radiotherapy and chemotherapy (SERA); 5-Artificial intelligence SE evaluation (AI-SEE); 6-Environmental stress echocardiography and air pollution (ESTER); 7-SE in repaired Tetralogy of Fallot (SETOF); 8-SE in post-COVID-19 (SECOV); 9: Recovery by stress echo of conventionally unfit donor good hearts (RESURGE); 10-SE for mitral ischemic regurgitation (SEMIR); 11-SE in valvular heart disease (SEVA); 12-SE for coronary vasospasm (SESPASM). The study aims to recruit in the next 5 years (2021-2025) ≥10,000 patients followed for ≥5 years (up to 2030) from ≥20 quality-controlled laboratories from ≥10 countries. In this COVID-19 era of sustainable health care delivery, SE2030 will provide the evidence to finally recommend SE as the optimal and versatile imaging modality for functional testing anywhere, any time, and in any patient.

Keywords: effectiveness; registry; stress echocardiography; sustainability.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
SE 2030 at a glance. The core protocol of SE2030 is the same as in SE2020 with ABCDE: epicardial coronary artery stenosis (with RWMA), step A; lung water (with B-lines), step B; myocardial function (with left ventricular end-systolic volume for contractile reserve and end-diastolic volume for preload reserve), step C; coronary microvascular dysfunction (with CFVR), step D; cardiac autonomic balance (with HRR), step E. Ancillary steps (necessary in some but not all patients) are step F (regurgitant flows), step L (left atrial volume and function), step P (pulmonary and LV pressures) and step R (right ventricular function). The study is endorsed by the Italian Society of Echocardiography and Cardiovascular Imaging and initiated in Pisa, Italy, as shown by the Leaning Tower present in the logo. SE protocols are indicated from 1 to 12 clockwise, and cover a wide spectrum of clinical conditions within and beyond CAD.
See this image and copyright information in PMC

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