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. 1987 Nov;22(11):925-6.
doi: 10.1007/BF02535556.

Distribution and metabolism of hexadecylphosphocholine in mice

A Breiser  1 , D J Kim, E A Fleer, W Damenz, A Drube, M Berger, G A Nagel, H Eibl, C Unger
Affiliations

Distribution and metabolism of hexadecylphosphocholine in mice

A Breiser et al. Lipids. 1987 Nov.

Abstract

Distribution and metabolic fate of radiolabeled hexadecylphosphocholine (He-PC) has been studied in mice. It is demonstrated that He-PC is well-absorbed from the intestinal tract, intravenous (IV) and oral administration lead to similar distributions throughout the body, the highest accumulation of radioactivity occurs in liver, lung and kidney, and the metabolic products are radioactive choline, phosphocholine and 1,2-diacylphosphatidylcholine. The occurrence of these metabolites indicates that phospholipases C and D may be involved in He-PC breakdown.

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