Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug 10;11(8):2030.
doi: 10.3390/nano11082030.

Ionic Liquids for Development of Heterogeneous Catalysts Based on Nanomaterials for Biocatalysis

Anna Wolny  1 , Anna Chrobok  1
Affiliations
Review

Ionic Liquids for Development of Heterogeneous Catalysts Based on Nanomaterials for Biocatalysis

Anna Wolny et al. Nanomaterials (Basel). .

Abstract

The development of effective methods of enzyme stabilization is key for the evolution of biocatalytic processes. An interesting approach combines the stabilization process of proteins in ionic liquids and the immobilization of the active phase on the solid support. As a result, stable, active and heterogeneous biocatalysts are obtained. There are several benefits associated with heterogeneous processes, as easy separation of the biocatalyst from the reaction mixture and the possibility of recycling. Accordingly, this work focused on the supported ionic liquid phases as the efficient enzyme stabilization carriers, and their application in both continuous flow and batch biocatalytic processes.

Keywords: biocatalysis; enzyme; heterogeneous catalysis; immobilization; nanomaterials; supported ionic liquid phase; supported ionic liquid-like phase.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the writing of the manuscript, or in the decision to publish.

Figures

Figure 1
Figure 1
Enzyme immobilized on the supports modified with ionic liquids.
Figure 2
Figure 2
Structures of ionic liquids used for enzyme stabilization.
Figure 3
Figure 3
Scheme of kinetic resolution of 1-phenylethanol racemate in SILP biocatalyst and scCO2 presence.
Figure 4
Figure 4
Presentation of enzyme immobilized on SILLP used in methanolysis of triolein under scCO2 conditions.
Figure 5
Figure 5
Scheme of MWCNTs chemical modifications with ionic liquids.
Figure 6
Figure 6
Scheme of Baeyer–Villiger oxidation of 2-adamantanone catalyzed by supported ionic liquid phase biocatalysts.
See this image and copyright information in PMC

References

    1. Scheldon R.A. The E factor 25 years on: The rise of green chemistry and sustainability. Green Chem. 2017;19:18–43. doi: 10.1039/C6GC02157C. - DOI
    1. Gottardo S., Mech A., Riego S., Sintes J., Rauscher H., Drbohlavova J., Malyska A., Bowadt S. Towards safe and sustainable in-novation in nanotechnology: State-of-play for smart nanomaterials. NanoImpact. 2021;21:100297. doi: 10.1016/j.impact.2021.100297. - DOI - PMC - PubMed
    1. Sheldon R.A., Arends I., Hanefeld U. Green Chemistry and Catalysis. Wiley-VCH Verlag GmbH; Berlin, Germany: 2020.
    1. Scheldon R.A., Woodley J.M. Role of biocatalysis in sustainable chemistry. Chem. Rev. 2018;118:801–838. doi: 10.1021/acs.chemrev.7b00203. - DOI - PubMed
    1. Fernandez-Lafuente R. Enzyme immobilization and its applications. Molecules. 2019;24:4619. doi: 10.3390/molecules24244619. - DOI - PMC - PubMed