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Multicenter Study
. 2021 Aug 12;13(8):2770.
doi: 10.3390/nu13082770.

Improvement of Lipid Profile after One-Anastomosis Gastric Bypass Compared to Sleeve Gastrectomy

Silvia Bettini  1   2 , Gianni Segato  3 , Luca Prevedello  2 , Roberto Fabris  2 , Chiara Dal Prà  2 , Eva Zabeo  2 , Chiara Compagnin  1 , Fabio De Luca  1 , Cristiano Finco  4 , Mirto Foletto  2 , Roberto Vettor  1   2 , Luca Busetto  1   2 , On Behalf Of The Veneto Obesity Network
Affiliations
Multicenter Study

Improvement of Lipid Profile after One-Anastomosis Gastric Bypass Compared to Sleeve Gastrectomy

Silvia Bettini et al. Nutrients. .

Abstract

Fewer studies compared the improvement of plasma lipid levels after different types of surgery, in particular compared to one-anastomosis gastric bypass (OAGB). The aim of our study was to investigate how laparoscopic sleeve gastrectomy (LSG) and OAGB impact on weight loss and lipid profile 18 months after surgery, in patients with severe obesity. Forty-six patients treated with OAGB were matched to eighty-eight patients submitted to LSG. Weight loss after OAGB (33.2%) was more evident than after LSG (29.6%) (p = 0.024). The difference in the prevalence of dyslipidemia showed a statistically significant reduction only after OAGB (61% versus 22%, p < 0.001). After adjustment for delta body mass index (BMI), age and sex, we demonstrated a statistically significant decrease of the differences between the changes before and after (delta Δ) the two surgery procedures: Δ total cholesterol values (p < 0.001), Δ low density lipoprotein-cholesterol values (p < 0.001) and Δ triglycerides values (p = 0.007). Patients with severe obesity undergoing to OAGB presented a better improvement of lipid plasma values than LSG patients. The reduction of lipid plasma levels was independent of the significant decrease of BMI after surgery, of age and of sex.

Keywords: HDL; LDL; dyslipidemia; lipid metabolism; lipoprotein; obesity; one-anastomosis gastric bypass one; sleeve gastrectomy; triglycerides.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Prevalence (percentage) of dyslipidemia before (black bars) and after (grey bars) laparoscopic sleeve gastrectomy (LSG) (n = 88) and one anastomosis gastric bypass (OAGB) (n = 46). Statistical analysis was performed by Chi-square test.
Figure 2
Figure 2
Difference between the changes (delta Δ) of Total Cholesterol (TC) (A), triglycerides (TG) (B), Low Density Lipoprotein-cholesterol (LDL) (C) and High Density Lipoprotein -cholesterol (HDL) (D) before and after Laparoscopic Sleeve Gastrectomy (LSG) and One Anastomosis Gastric Bypass (OAGB). Statistical analysis was performed by Mann-Whitney Rank Sum Test for the comparison between delta; multiple regression model for the adjustment for Δ BMI, sex and age.
See this image and copyright information in PMC

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