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. 1979 Jan;6(1):31-7.
doi: 10.1002/bms.1200060108.

The analysis of terbutaline in biological fluids by gas chromatography electron impace mass spectrometry

R A Clare, D S Davies, T A Baillie

The analysis of terbutaline in biological fluids by gas chromatography electron impace mass spectrometry

R A Clare et al. Biomed Mass Spectrom. 1979 Jan.

Abstract

A highly sensitive and specific assay is described for the bronchodilator drug terbutaline in human plasma and urine, based on single ion monitoring gas chromatography mass spectrometry and employing a homologue of the drug as internal standard. Recovery of terbutaline and internal standard into ethyl acetate is effected at pH 9.8, while back-extraction into dilute acid serves to purify the initial extract. Following preparation of O-TMS, N-TFA derivatives, the drug and its homologue are detected by selected ion monitoring of their common base ion at m/e 355. The limit of detection of terbutaline by this procedure is 0.3 ng ml-1 from a 4 ml sample of plasma.

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