. 2021 Nov 11;58(5):2101786.

doi: 10.1183/13993003.01786-2021. Print 2021 Nov.

Gauging the impact of the COVID-19 pandemic on tuberculosis services: a global study

Giovanni Battista Migliori¹, Pei Min Thong², Jan-Willem Alffenaar^{3

4

5}, Justin Denholm^{6

7}, Marina Tadolini^{8

9}, Fatma Alyaquobi¹⁰, François-Xavier Blanc¹¹, Danilo Buonsenso¹², Jin-Gun Cho^{4

5

13}, Luigi Ruffo Codecasa¹⁴, Edvardas Danila¹⁵, Raquel Duarte¹⁶, José-María García-García¹⁷, Gina Gualano¹⁸, Adrian Rendon¹⁹, Denise Rossato Silva²⁰, Mahamadou Bassirou Souleymane²¹, Sai Meng Tham²², Tania A Thomas²³, Simon Tiberi^{24

25}, Zarir F Udwadia²⁶, Delia Goletti¹⁸, Rosella Centis¹, Lia D'Ambrosio²⁷, Giovanni Sotgiu²⁸, Catherine W M Ong^{29

22

30}; Global Tuberculosis Network

Affiliations

¹ Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy.
² Dept of Medicine, Infectious Disease Translational Research Programme, National University of Singapore, Yong Loo Lin School of Medicine, Singapore.
³ The University of Sydney, Pharmacy School, Sydney, Australia.
⁴ Westmead Hospital, Sydney, Australia.
⁵ Marie Bashir Institute of Infectious Diseases and Biosecurity, The University of Sydney, Sydney, Australia.
⁶ Melbourne Health Victorian Tuberculosis Program, Melbourne, Australia.
⁷ Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
⁸ Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.
⁹ Dept of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
¹⁰ TB and Acute Respiratory Diseases Section, Dept of Communicable Diseases, Directorate General of Disease Surveillance and Control, Ministry of Health, Oman.
¹¹ Centre Hospitalier Universitaire, Nantes, France.
¹² Dept of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
¹³ Parramatta Chest Clinic, Parramatta, Australia.
¹⁴ TB Reference Centre, Villa Marelli Institute, Niguarda Hospital, Milan, Italy.
¹⁵ Clinic of Chest Diseases, Immunology and Allergology, Vilnius University Medical Faculty, Centre of Pulmonology and Allergology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
¹⁶ National Reference Centre for MDR-TB, Hospital Centre Vila Nova de Gaia, Dept of Pneumology, Public Health Science and Medical Education Dept, Faculty of Medicine, University of Porto, Porto, Portugal.
¹⁷ Tuberculosis Research Programme (PII-TB) SEPAR, Barcelona, Spain.
¹⁸ National Institute for Infectious Diseases (INMI) 'L. Spallanzani' - IRCCS, Rome, Italy.
¹⁹ Centro de Investigación, Prevención y Tratamiento de Infecciones Respiratorias CIPTIR, University Hospital of Monterrey UANL (Universidad Autonoma de Nuevo Leon) Monterrey, Monterrey, Mexico.
²⁰ Faculdade de Medicina, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brasil.
²¹ Damien Foundation, Niamey, Niger.
²² Division of Infectious Diseases, Dept of Medicine, National University Hospital, Singapore.
²³ Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA.
²⁴ Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, UK.
²⁵ Royal London Hospital, Barts Health National Health Service Trust, London, UK.
²⁶ P.D. Hinduja National Hospital and Medical research Centre, Mumbai, India.
²⁷ Public Health Consulting Group, Lugano, Switzerland.
²⁸ Clinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
²⁹ Dept of Medicine, Infectious Disease Translational Research Programme, National University of Singapore, Yong Loo Lin School of Medicine, Singapore catherine_wm_ong@nuhs.edu.sg.
³⁰ National University of Singapore Institute for Health Innovation & Technology (iHealthtech), Singapore.

PMID: 34446465
PMCID: PMC8581650
DOI: 10.1183/13993003.01786-2021

Gauging the impact of the COVID-19 pandemic on tuberculosis services: a global study

Giovanni Battista Migliori et al. Eur Respir J. 2021.

. 2021 Nov 11;58(5):2101786.

doi: 10.1183/13993003.01786-2021. Print 2021 Nov.

Authors

Affiliations

¹ Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy.
² Dept of Medicine, Infectious Disease Translational Research Programme, National University of Singapore, Yong Loo Lin School of Medicine, Singapore.
³ The University of Sydney, Pharmacy School, Sydney, Australia.
⁴ Westmead Hospital, Sydney, Australia.
⁵ Marie Bashir Institute of Infectious Diseases and Biosecurity, The University of Sydney, Sydney, Australia.
⁶ Melbourne Health Victorian Tuberculosis Program, Melbourne, Australia.
⁷ Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
⁸ Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.
⁹ Dept of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
¹⁰ TB and Acute Respiratory Diseases Section, Dept of Communicable Diseases, Directorate General of Disease Surveillance and Control, Ministry of Health, Oman.
¹¹ Centre Hospitalier Universitaire, Nantes, France.
¹² Dept of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
¹³ Parramatta Chest Clinic, Parramatta, Australia.
¹⁴ TB Reference Centre, Villa Marelli Institute, Niguarda Hospital, Milan, Italy.
¹⁵ Clinic of Chest Diseases, Immunology and Allergology, Vilnius University Medical Faculty, Centre of Pulmonology and Allergology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
¹⁶ National Reference Centre for MDR-TB, Hospital Centre Vila Nova de Gaia, Dept of Pneumology, Public Health Science and Medical Education Dept, Faculty of Medicine, University of Porto, Porto, Portugal.
¹⁷ Tuberculosis Research Programme (PII-TB) SEPAR, Barcelona, Spain.
¹⁸ National Institute for Infectious Diseases (INMI) 'L. Spallanzani' - IRCCS, Rome, Italy.
¹⁹ Centro de Investigación, Prevención y Tratamiento de Infecciones Respiratorias CIPTIR, University Hospital of Monterrey UANL (Universidad Autonoma de Nuevo Leon) Monterrey, Monterrey, Mexico.
²⁰ Faculdade de Medicina, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brasil.
²¹ Damien Foundation, Niamey, Niger.
²² Division of Infectious Diseases, Dept of Medicine, National University Hospital, Singapore.
²³ Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA.
²⁴ Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, UK.
²⁵ Royal London Hospital, Barts Health National Health Service Trust, London, UK.
²⁶ P.D. Hinduja National Hospital and Medical research Centre, Mumbai, India.
²⁷ Public Health Consulting Group, Lugano, Switzerland.
²⁸ Clinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
²⁹ Dept of Medicine, Infectious Disease Translational Research Programme, National University of Singapore, Yong Loo Lin School of Medicine, Singapore catherine_wm_ong@nuhs.edu.sg.
³⁰ National University of Singapore Institute for Health Innovation & Technology (iHealthtech), Singapore.

PMID: 34446465
PMCID: PMC8581650
DOI: 10.1183/13993003.01786-2021

Abstract

This global study of 43 TB centres from 19 countries demonstrates the impact of COVID-19 pandemic on TB services. Newly diagnosed TB disease, drug-resistant TB, TB deaths, outpatient clinic attendances and newly diagnosed TB infection were reduced. https://bit.ly/3sdHbfk

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Conflict of interest statement

Conflict of interest: G.B. Migliori has nothing to disclose. Conflict of interest: P.M. Thong has nothing to disclose. Conflict of interest: J-W. Alffenaar has nothing to disclose. Conflict of interest: J. Denholm has nothing to disclose. Conflict of interest: M. Tadolini has nothing to disclose. Conflict of interest: F. Alyaquobi has nothing to disclose. Conflict of interest: F-X. Blanc has nothing to disclose. Conflict of interest: D. Buonsenso has nothing to disclose. Conflict of interest: J-G. Cho has nothing to disclose. Conflict of interest: L.R. Codecasa has nothing to disclose. Conflict of interest: E. Danila has nothing to disclose. Conflict of interest: R. Duarte has nothing to disclose. Conflict of interest: J-M. García-García has nothing to disclose. Conflict of interest: G. Gualano has nothing to disclose. Conflict of interest: A. Rendon has nothing to disclose. Conflict of interest: D.R. Silva has nothing to disclose. Conflict of interest: M.B. Souleymane has nothing to disclose. Conflict of interest: S.M. Tham has nothing to disclose. Conflict of interest: T.A. Thomas has nothing to disclose. Conflict of interest: S. Tiberi has nothing to disclose. Conflict of interest: Z.F. Udwadia has nothing to disclose. Conflict of interest: D. Goletti has nothing to disclose. Conflict of interest: R. Centis has nothing to disclose. Conflict of interest: L. D'Ambrosio has nothing to disclose. Conflict of interest: G. Sotgiu has nothing to disclose. Conflict of interest: C.W.M. Ong reports grants from National Medical Research Council (CSAINV17nov014), personal fees (young investigator award) from Institut Merieux, during the conduct of the study; other (honorarium) from Qiagen, outside the submitted work.

Figures

**FIGURE 1**
a) Countries of the participating centres of the study. State-wide and/or regional data were collected from Australia (Victoria), Oman, Paraguay, Portugal (Northern Portugal), Russia (Moscow and Arkangelsk Region/Oblast) and USA (Virginia). b–i) Tuberculosis (TB) disease and infection trends in 2019 and 2020. b) TB disease; c) TB disease discharged from hospital; d) drug-resistant TB disease diagnosed; e) TB deaths; f) newly diagnosed TB disease in outpatient clinics; g) telehealth use for TB disease in outpatient clinics; h) newly diagnosed TB infection across centres; i) latent TB tests comprising of tuberculin skin tests and interferon-γ release assays performed. Data from Moscow and Paraguay are excluded from h) and i) as only annual data are available from these two centres.

See this image and copyright information in PMC

Comment in

War in Ukraine: an immense threat to the fight against tuberculosis.
Dahl V, Migliori GB, Lange C, Wejse C. Dahl V, et al. Eur Respir J. 2022 Apr 21;59(4):2200493. doi: 10.1183/13993003.00493-2022. Print 2022 Apr. Eur Respir J. 2022. PMID: 35450921 No abstract available.

References

1. Dara M, Sotgiu G, Reichler MR, et al. . New diseases and old threats: lessons from tuberculosis for the COVID-19 response. Int J Tuberc Lung Dis 2020; 24: 544–545. doi:10.5588/ijtld.20.0151 - DOI - PubMed
1. Alagna R, Besozzi G, Codecasa LR, et al. . Celebrating World Tuberculosis Day at the time of COVID-19. Eur Respir J 2020; 55: 2000650. doi:10.1183/13993003.00650-2020 - DOI - PMC - PubMed
1. Tadolini M, Codecasa LR, Garcia-Garcia JM, et al. . Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases. Eur Respir J 2020; 56: 2001398. - PMC - PubMed
1. Motta I, Centis R, D'Ambrosio L, et al. . Tuberculosis, COVID-19 and migrants: preliminary analysis of deaths occurring in 69 patients from two cohorts. Pulmonology 2020; 26: 233–240. doi:10.1016/j.pulmoe.2020.05.002 - DOI - PMC - PubMed
1. Buonsenso D, Iodice F, Sorba Biala J, et al. . COVID-19 effects on tuberculosis care in Sierra Leone. Pulmonology 2020; 27: 67–69. doi:10.1016/j.pulmoe.2020.05.013 - DOI - PMC - PubMed

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Gauging the impact of the COVID-19 pandemic on tuberculosis services: a global study

Affiliations

Gauging the impact of the COVID-19 pandemic on tuberculosis services: a global study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Comment in

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

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