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Comment
. 2021 Aug 27;373(6558):967-968.
doi: 10.1126/science.abl3631.

Immune imprinting in utero

Mohammed Amir  1 , Melody Y Zeng  2   3
Affiliations
Comment

Immune imprinting in utero

Mohammed Amir et al. Science. .
No abstract available

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Figures

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Shaping immune development in utero
Fetal immune development is sensitive to changes in the dam, including gut microbiota, diet, and inflammation, such as from vaccination. A mild, maternally restricted infection may lead to interleukin-6 (IL-6)–induced epigenetic imprinting in fetal intestinal epithelium and intestinal T helper 17 (TH17) cells in adult offspring. As a result, the adult offspring have enhanced immunity against enteric pathogens but may also be more susceptible to gut inflammation.
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