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Review
. 2021 Jun;13(Suppl 1):S6-S10.
doi: 10.4103/jpbs.JPBS_563_20. Epub 2021 Jun 5.

Fibroblastic Growth Factor as a Diagnostic and Prognostic Marker in Odontogenic Cysts and Tumors: A Systematic Review

Gururaj Narayana Rao  1 , Adlin Saroja Rosaian  1 , Gowthami Jawahar  1 , P Hari Nivas Raj  1 , J Beryl Rachel  1 , P Blessing Emmanuel  2
Affiliations
Review

Fibroblastic Growth Factor as a Diagnostic and Prognostic Marker in Odontogenic Cysts and Tumors: A Systematic Review

Gururaj Narayana Rao et al. J Pharm Bioallied Sci. 2021 Jun.

Abstract

Cellular signaling proteins maintain the basic activities of cell and communication, between the cells for normal growth and development and pathological situation as well. Fibroblast growth factor (FGF) and fibroblast growth factor receptors (FGFRs) have a comparatively huge part to play in the cellular communication processes. Human FGF has 22 members, 18 ligands, and 4 tyrosine kinase receptors for binding and is expressed in a wide range of cells. Any alteration in these factors would disrupt their normal function, leading to various abnormalities. The aim of this systematic analysis, is to understand the FGFs, the physiological and pathological role of FGF in oral diseases, and to predict the use of FGF in the predilection toward odontogenic cyst and tumors. This review helps confer the role of FGF in various physiological and pathological aspects in systemic diseases and analyzes its role in diagnosis and prognosis of odontogenic cysts and tumors.

Keywords: Fibroblast growth factor; mutations; odontogenic tumors and cyst; receptor signaling.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flowchart of the systematic review
See this image and copyright information in PMC

References

    1. Khalid A, Javaid MA. Fibroblast growth factors and their emerging cancer related aspects. J Cancer Sci Ther. 2016;8:190–205.
    1. Ghedini GC, Ronca R, Presta M, Giacomini A. Future applications of FGF/FGFR inhibitors in cancer. Exp Rev Anticancer Ther. 2018;18:861–72. - PubMed
    1. Du W, Du W, Yu H. The role of fibroblast growth factors in tooth development and incisor renewal. Stem Cells Int. 2018;2018:7549160. - PMC - PubMed
    1. Ornitz1 DM, Itoh N. The fibroblast growth factor signaling pathway. Wiley Interdiscip Rev Dev Biol. 2015;4:215–66. - PMC - PubMed
    1. Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2010;141:1117–34. - PMC - PubMed