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Review
. 2021 Oct;43(10):1945-1954.
doi: 10.1007/s10529-021-03173-3. Epub 2021 Aug 26.

The application of oncolytic viruses in cancer therapy

Yang Gao  1 , Yan Wu  1 , Tian Huan  1 , Xiaoyan Wang  2 , Jun Xu  3 , Qinggang Xu  1 , Feng Yu  4 , Haifeng Shi  5
Affiliations
Review

The application of oncolytic viruses in cancer therapy

Yang Gao et al. Biotechnol Lett. 2021 Oct.

Abstract

Oncolytic therapy is a treatment method used to directly combat tumor cells by modifying the genes of naturally occurring low pathogenic viruses to form "rhizobia" virus. By taking the advantage of abnormal signal pathways in cancer cells, it selectively replicates in tumor cells leading to tumor cell lysis and death. At present, clinical studies widely employ biomolecular technology to transform oncolytic viruses to exert stronger oncolytic effects and reduce their adverse reactions. This review summarizes the current progresses and the molecular mechanism of oncolytic viruses towards tumor treatment and management.

Keywords: Cancer therapy; Immune response; Molecular mechanism; Oncolytic virus.

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References

    1. Bell JC, McFadden G (2015) Editorial overview: oncolytic viruses-replicating virus therapeutics for the treatment of cancer. Curr Opin Virol 13:viii–ix - PubMed - DOI
    1. Bommareddy PK, Shettigar M, Kaufman HL (2018) Integrating oncolytic viruses in combination cancer immunotherapy. Nat Rev Immunol 18(8):498–513 - PubMed - DOI
    1. Boutros C, Tarhini A, Routier E et al (2016) Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination. Nat Rev Clin Oncol 13(8):473–486 - PubMed - DOI
    1. Card PB, Hogg RT, Gil Del Alcazar CR, Gerard RD (2012) MicroRNA silencing improves the tumor specificity of adenoviral transgene expression. Cancer Gene Ther 19(7):451–459 - PubMed - PMC - DOI
    1. Chaurasiya S, Fong Y, Warner SG (2020) Optimizing oncolytic viral design to enhance antitumor efficacy: progress and challenges. Cancers (Basel) 12(6):1699 - DOI

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