Pharmaceutical applications of powder-based binder jet 3D printing process - A review

Koyel Sen¹, Tanu Mehta¹, Sameera Sansare¹, Leila Sharifi², Anson W K Ma³, Bodhisattwa Chaudhuri⁴

Affiliations

¹ Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.
² Department of Pharmaceutical Sciences, Islamic Azad University of Tehran, Tehran, Iran.
³ Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, USA; Institute of Material Sciences, University of Connecticut, Storrs, CT, USA.
⁴ Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA; Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, USA; Institute of Material Sciences, University of Connecticut, Storrs, CT, USA. Electronic address: bodhi.chaudhuri@uconn.edu.

PMID: 34450238
DOI: 10.1016/j.addr.2021.113943

Review

Pharmaceutical applications of powder-based binder jet 3D printing process - A review

Koyel Sen et al. Adv Drug Deliv Rev. 2021 Oct.

. 2021 Oct:177:113943.

doi: 10.1016/j.addr.2021.113943. Epub 2021 Aug 25.

Authors

Koyel Sen¹, Tanu Mehta¹, Sameera Sansare¹, Leila Sharifi², Anson W K Ma³, Bodhisattwa Chaudhuri⁴

Affiliations

¹ Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.
² Department of Pharmaceutical Sciences, Islamic Azad University of Tehran, Tehran, Iran.
³ Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, USA; Institute of Material Sciences, University of Connecticut, Storrs, CT, USA.
⁴ Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA; Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, USA; Institute of Material Sciences, University of Connecticut, Storrs, CT, USA. Electronic address: bodhi.chaudhuri@uconn.edu.

PMID: 34450238
DOI: 10.1016/j.addr.2021.113943

Abstract

Pharmaceutical applications of the 3D printing process have recently matured, followed by the FDA approval of Spritam, the first commercial 3D printed dosage form. Due to being a new technology in the conventional dosage formulation field, there is still a dearth of understanding in the 3D printing process regarding the effect of the raw materials on the printed dosage forms and the plausibility of using this technology in dosage development beyond the conventional ways. In this review, the powder-based binder jet 3D printing (BJ3DP) process and its pharmaceutical applications have been discussed, along with a perspective of the formulation development step. The recent applications of BJ3DP in pharmaceutical dosage development, the advantages, and limitations have further been discussed here. A discussion of the critical formulation parameters that need to be explored for the preformulation study of the solid oral dosage development using the BJ3DP process is also presented.

Keywords: 3D printing; Binder-jet; Pharmaceutical dosage form; Solid oral dosage form.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Pharmaceutical applications of powder-based binder jet 3D printing process - A review

Affiliations

Pharmaceutical applications of powder-based binder jet 3D printing process - A review

Authors

Affiliations

Abstract

Conflict of interest statement

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MeSH terms

Substances

LinkOut - more resources

Full Text Sources