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Review
. 2021 Aug 9;13(16):2642.
doi: 10.3390/polym13162642.

Current Insights into Collagen Type I

Ruth Naomi  1 , Pauzi Muhd Ridzuan  2 , Hasnah Bahari  1
Affiliations
Review

Current Insights into Collagen Type I

Ruth Naomi et al. Polymers (Basel). .

Abstract

Collagen type I (Col-I) is unique due to its high biocompatibility in human tissue. Despite its availability from various sources, Col-I naturally mimics the extracellular matrix (ECM) and generally makes up the larger protein component (90%) in vasculature, skin, tendon bone, and other tissue. The acceptable physicochemical properties of native Col-I further enhance the incorporation of Col-I in various fields, including pharmaceutical, cosmeceutical, regenerative medicine, and clinical. This review aims to discuss Col-I, covering the structure, various sources of availability, native collagen synthesis, current extraction methods, physicochemical characteristics, applications in various fields, and biomarkers. The review is intended to provide specific information on Col-I currently available, going back five years. This is expected to provide a helping hand for researchers who are concerned about any development on collagen-based products particularly for therapeutic fields.

Keywords: collagen type I; extracellular matrix; extraction; physicochemical; regenerative medicine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of Col-I.
Figure 2
Figure 2
Sources of Col-I.
Figure 3
Figure 3
Synthesize of Col-I.
Figure 4
Figure 4
Col-I in bone repair. Figure is reused from Rupani et al. (2012) [121]. Used under the Creative Commons Attribution—Non Commercial (unported, v3.0) License. http://creativecommons.org/licenses/by-nc/3.0/ accessed on 8 May 2012.
See this image and copyright information in PMC

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