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. 2021 Aug 8;14(8):778.
doi: 10.3390/ph14080778.

The Positive Correlations between the Expression of Histopathological Ubiquitin-Conjugating Enzyme 2O Staining and Prostate Cancer Advancement

Jae-Heon Kim  1   2 , Hee-Jo Yang  3 , Chang-Ho Lee  3 , Youn-Soo Jeon  3 , Jae-Joon Park  1 , Kwang-Woo Lee  4 , Jae-Ho Kim  5 , Su-Yeon Park  6   7 , Su-Jung Song  8   9 , Yon-Hee Kim  10 , Ah-Rim Moon  11 , Ji-Hye Lee  12 , Yun-Seob Song  1
Affiliations

The Positive Correlations between the Expression of Histopathological Ubiquitin-Conjugating Enzyme 2O Staining and Prostate Cancer Advancement

Jae-Heon Kim et al. Pharmaceuticals (Basel). .

Abstract

Background: The mTOR signaling pathway is inactivated by AMPK's tumor-suppressing function. It is recognized that ubiquitin conjugating enzyme 2O (UBE2O), which directly targets AMPK for ubiquitination and degradation, is intensified in human cancers.

Methods: This study investigated the clinical data about prostate cancer. Examination was also carried out into tissue microarrays (TMA) of human prostate cancer (n = 382) and adjacent non-neoplastic tissues around prostate cancer (n = 61). The TMA slides were incubated with antibodies against UBE2O, and the cores were scored by the pathologist blind to cancer results.

Results: Very strong positive correlations were identified between the expression of UBE2O staining and high PSA and pathological stage of prostate cancer. Cox's proportional hazard analysis established correlations between the following: (1) positive surgical margin and biochemical recurrence free survival, (2) PSA grade and clinical recurrence free survival, (3) regional lymph node positive and clinical recurrence free survival, (4) adjuvant treatment and overall survival, and (5) pathological T stage and overall survival.

Conclusion: There is a positive correlation between the expression of UBE2O staining and prognosis for prostate cancer. Thus, a prostate cancer prognosis can be assessed with the expression of UBE2O staining.

Keywords: UBE2O; prostate cancer; ubiquitin.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Different expression of UBE20 in non-neoplastic and neoplastic tissues. UBE2O grade—0: negative, 1: weak 2: moderate, 3: strong. (×400).
Figure 2
Figure 2
Different expression of UBE20 in neoplastic tissue and non-neoplastic tissue. (A) Expression score of UBE20 in right side (neoplastic tissue) was 3 and was 1 in left side (non-neoplastic tissue) with preservation of basal cell. (×200) (B) Expression score of UBE20 in left side (non-neoplastic tissue) was 3 and was 1 in right side (neoplastic tissue) with preservation of basal cell (×400).
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